{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:39:06Z","timestamp":1790440746000,"version":"4.1.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,1,8]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light\u2010intensity physical activity or moderate\u2010to\u2010vigorous intensity physical activity; however, existing studies are limited by cross\u2010sectional study designs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Participants were 1922 adults from the\n              <jats:styled-content style=\"fixed-case\">CARDIA<\/jats:styled-content>\n              (Coronary Artery Risk Development in Young Adults) study. Linear regression examined the associations of sedentary, light\u2010intensity physical activity, and moderate\u2010to\u2010vigorous intensity physical activity at year 20 (2005\u20132006) with waist circumference, blood pressure, glucose, insulin, triglycerides,\n              <jats:styled-content style=\"fixed-case\">high\u2010density lipoprotein<\/jats:styled-content>\n              cholesterol, and a composite risk score at year 30 (2015\u20132016). Models then examined change in activity with change in cardiometabolic risk over the same 10\u2010year period. Replacing 30\u00a0min\/day of sedentary time with 30\u00a0min\/day of light\u2010intensity physical activity at year 20 was associated with a lower composite risk score (\u22120.01\n              <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n              [95% CI, \u22120.02, \u22120.00]) at year 30, characterized by lower waist circumference (0.15\u00a0cm [95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              \u22120.27, 0.02]), insulin (0.20\u00a0\u03bcU\/mL [95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              \u22120.35, \u22120.04]), and higher\n              <jats:styled-content style=\"fixed-case\">high\u2010density lipoprotein<\/jats:styled-content>\n              cholesterol (0.20\u00a0mg\/dL [95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              0.00, 0.40]; all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). An increase of 30\u00a0min\/day in\n              <jats:styled-content style=\"fixed-case\">MVPA<\/jats:styled-content>\n              from year 20 to year 30, when replacing an equivalent increase in sedentary time, was associated with a decrease in the composite risk score (\u22120.08 [95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              \u22120.13, \u22120.04]) over the same 10 years, characterized by a decrease in waist circumference (1.52\u00a0cm [95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              \u22122.21, \u22120.84]), insulin (\u22121.13\u00a0\u03bcU\/mL [95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              \u22121.95, \u22120.31]), triglycerides (\u22126.92\u00a0mg\/dL [95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              \u221211.69, \u22122.15]), and an increase in\n              <jats:styled-content style=\"fixed-case\">high\u2010density lipoprotein<\/jats:styled-content>\n              cholesterol (1.59\u00a0mg\/dL [95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              0.45, 2.73]; all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Replacement of sedentary time with light\u2010intensity physical activity or moderate\u2010to\u2010vigorous intensity physical activity is associated with improved cardiometabolic health 10\u00a0years later.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.010212","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T10:25:04Z","timestamp":1546943104000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":58,"title":["Associations of Accelerometer\u2010Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk\u00a0Factors: The CARDIA Study"],"prefix":"10.1161","volume":"8","author":[{"given":"Kara M.","family":"Whitaker","sequence":"first","affiliation":[{"name":"Department of Health and Human Physiology College of Liberal Arts &amp; Sciences University of Iowa Iowa City IA"},{"name":"Department of Epidemiology College of Public Health University of Iowa Iowa City IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley","family":"Pettee Gabriel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics, and Environmental Sciences School of Public Health University of Texas Health Science Center at Houston Austin TX"},{"name":"Department of Women's Health Dell Medical School University of Texas at Austin Austin TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Buman","sequence":"additional","affiliation":[{"name":"College of Health Solutions Arizona State University Phoenix AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"David R.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared P.","family":"Reis","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Sciences National Heart, Lung, and Blood Institute Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany Barone","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Department of Health and Physical Activity University of Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes R.","family":"Carnethon","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Feinberg School of Medicine Northwestern University Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Staudenmayer","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics University of Massachusetts Amherst MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Sidney","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California Oakland CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Sternfeld","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California Oakland CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2015.04.013"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-014-0090-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00426-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0493"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181d322ac"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.05.004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp163"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq249"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-016-0725-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-9-47"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt292"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv308"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2015.04.005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487315619734"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000651"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000317"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119140"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175496"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001002"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1123\/jpah.2017-0102"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-015-0280-7"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000885"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.135129"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S151613"},{"key":"e_1_3_2_26_2","unstructured":"Coronary Artery Risk Development in Young Adults: New Investigators. 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