{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:30:08Z","timestamp":1787499008588,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,11,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The lymphatic system has been suggested to play an important role in cholesterol metabolism and cardiovascular disease. However, the relationships of vascular endothelial growth factor\u2010C (\n                      <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                      \u2010C), a central player in lymphangiogenesis, with mortality and cardiovascular events in patients with suspected or known coronary artery disease are unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We performed a multicenter, prospective cohort study of 2418 patients with suspected or known coronary artery disease undergoing elective coronary angiography. The primary predictor was serum levels of\n                      <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                      \u2010C. The primary outcome was all\u2010cause death. The secondary outcomes were cardiovascular death, and major adverse cardiovascular events defined as a composite of cardiovascular death, non\u2010fatal myocardial infarction, and non\u2010fatal stroke. During the 3\u2010year follow\u2010up, 254 patients died from any cause, 88 died from cardiovascular disease, and 165 developed major adverse cardiovascular events. After adjustment for established risk factors,\n                      <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                      \u2010C levels were significantly and inversely associated with all\u2010cause death (hazard ratio for 1\u2010\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      increase, 0.69; 95% confidence interval, 0.60\u20130.80) and cardiovascular death (hazard ratio, 0.67; 95% confidence interval, 0.53\u20130.87), but not with major adverse cardiovascular events (hazard ratio, 0.85; 95% confidence interval, 0.72\u20131.01). Even after incorporation of N\u2010terminal pro\u2010brain natriuretic peptide, contemporary sensitive cardiac troponin\u2010I, and high\u2010sensitivity C\u2010reactive protein into a model with established risk factors, the addition of\n                      <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                      \u2010C levels further improved the prediction of all\u2010cause death, but not that of cardiovascular death or major adverse cardiovascular events. Consistent results were observed within 1717 patients with suspected coronary artery disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In patients with suspected or known coronary artery disease, a low\n                      <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                      \u2010C value may independently predict all\u2010cause mortality.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.118.010355","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T05:04:48Z","timestamp":1540443888000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["VEGF\u2010C and Mortality in Patients With Suspected or Known Coronary 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