{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:31:59Z","timestamp":1787239919906,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,3,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      It has been suggested that endocardial and epicardial ablation of ventricular tachycardia (\n                      <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n                      ) improves outcome in arrhythmogenic right ventricular cardiomyopathy\/dysplasia. We investigated our sequential approach for\n                      <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n                      ablation in patients with arrhythmogenic right ventricular cardiomyopathy\/dysplasia in a single center.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We included 47 patients (44\u00b116\u00a0years) with definite (81%) or borderline (19%) arrhythmogenic right ventricular cardiomyopathy\/dysplasia between 1998 and 2016. Our ablation strategy was to target the endocardial substrate. Epicardial ablation was performed in case of acute ablation failure or lack of an endocardial substrate. Single and multiple procedural 1\u2010 and 5\u2010year outcome data for the first occurrence of the study end points (sustained\n                      <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n                      \/ventricular fibrillation, heart transplant, and death after the index procedure, and sustained\n                      <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n                      \/ventricular fibrillation for multiple procedures) are reported. Eighty\u2010one radiofrequency ablation procedures were performed (mean 1.7 per patient, range 1\u20134). Forty\u2010five (56%) ablation procedures were performed via an endocardial, 11 (13%) via an epicardial, and 25 (31%) via a combined endo\u2010 and epicardial approach. Complete acute success was achieved in 65 (80%) procedures, and partial success in 13 (16%). After a median follow\u2010up of 50.8 (interquartile range, [18.6; 99.2]) months after the index procedure, 17 (36%) patients were free from the primary end point. After multiple procedures, freedom from sustained\n                      <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n                      \/ventricular fibrillation was 63% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 52\u201375) at 1\u00a0year, and 45% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 34\u201361) at 5\u00a0years, with 36% of patients receiving only endocardial radiofrequency ablation. A trend (log rank\n                      <jats:italic>P<\/jats:italic>\n                      =0.058) towards an improved outcome using a combined endo\u2010\/epicardial approach was observed after multiple procedures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Endocardial ablation can be effective in a considerable number of arrhythmogenic right ventricular cardiomyopathy\/dysplasia patients with\n                      <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n                      , potentially obviating the need for an epicardial approach.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.118.010365","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T05:02:18Z","timestamp":1551330138000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Catheter Ablation of Ventricular Tachycardia in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy\/Dysplasia: A Sequential Approach"],"prefix":"10.1161","volume":"8","author":[{"given":"Shibu","family":"Mathew","sequence":"first","affiliation":[{"name":"Department of Cardiology Asklepios Klinik St. Georg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardan M.","family":"Saguner","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asklepios Klinik St. Georg Hamburg Germany"},{"name":"Department of Cardiology University Heart Center Zurich 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