{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:28:45Z","timestamp":1780410525348,"version":"3.54.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,1,22]]},"abstract":"\n Background<\/jats:title>\n \n Intrauterine growth retardation (\n IUGR<\/jats:styled-content>\n ) is related to pulmonary artery hypertension in adults, and mi\n croRNA<\/jats:styled-content>\n \u2010206 (miR\u2010206) is proposed to affect the proliferation and apoptosis of pulmonary artery smooth muscle cells (\n PASMC<\/jats:styled-content>\n s) via post\u2010transcriptional regulation.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In an\n IUGR<\/jats:styled-content>\n rat model, we found that the expression and function of potassium voltage\u2010gated channel subfamily A member 5 (Kv1.5) in\n PASMC<\/jats:styled-content>\n s was inhibited, and pulmonary artery hypertension was exaggerated after chronic hypoxia (\n CH<\/jats:styled-content>\n ) treatment as adults. micro\n RNA<\/jats:styled-content>\n expression was investigated in\n PASMC<\/jats:styled-content>\n s from 12\u2010week\u2010old male\n IUGR<\/jats:styled-content>\n rats with\n CH<\/jats:styled-content>\n by microarray, polymerase chain reaction, and in\u00a0situ hybridization. The expression levels of Kv1.5 in primary cultured\n PASMC<\/jats:styled-content>\n s and pulmonary artery smooth muscle from\n IUGR<\/jats:styled-content>\n or control rats were evaluated with and without application of an miR\u2010206 inhibitor. Right ventricular systolic pressure, cell proliferation, luciferase reporter assay, and\n \n I<\/jats:italic>\n K<\/jats:sub>\n <\/jats:styled-content>\n v<\/jats:sub>\n were also calculated. We found increased expression of miR\u2010206 in resistance pulmonary arteries of\n IUGR<\/jats:styled-content>\n rats at 12\u00a0weeks compared with newborns. Application of an miR\u2010206 inhibitor in\u00a0vivo or in\u00a0vitro increased expression of Kv1.5 \u03b1\u2010protein and\n KCNA<\/jats:styled-content>\n 5. Also, decreased right ventricular systolic pressure and cell proliferation were observed in\n PASMC<\/jats:styled-content>\n s from 12\u2010week\u2010old control and\n IUGR<\/jats:styled-content>\n rats after\n CH<\/jats:styled-content>\n , while inhibitor did not significantly affect control and\n IUGR<\/jats:styled-content>\n rats.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These results suggest that expression of Kv1.5 and 4\u2010aminopyridine (Kv channel special inhibitor)\u2010sensitive Kv current were correlated with the inhibition of miR\u2010206 in\n PA<\/jats:styled-content>\n rings of\n IUGR<\/jats:styled-content>\n \u2010\n CH<\/jats:styled-content>\n rats and cultured\n IUGR PASMC<\/jats:styled-content>\n s exposed to hypoxia. Thus, miR\u2010206 may be a trigger for induction of exaggerated CH\u2013pulmonary artery hypertension of\n IUGR<\/jats:styled-content>\n via Kv1.5.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.010456","type":"journal-article","created":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T10:00:36Z","timestamp":1547287236000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Increased Expression of MicroRNA\u2010206 Inhibits Potassium Voltage\u2010Gated Channel Subfamily A Member 5 in Pulmonary Arterial Smooth Muscle Cells and Is Related to Exaggerated Pulmonary Artery Hypertension Following Intrauterine Growth Retardation in Rats"],"prefix":"10.1161","volume":"8","author":[{"given":"Ying","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Pediatric Health Care the Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linchen","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neonatology the Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neonatology the Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neonatology the Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neonatology the Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neonatology the Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neonatology the Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neonatology the Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neonatology the Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neonatology the Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neonatology the Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province People's Republic of 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