{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:43:08Z","timestamp":1790642588505,"version":"4.1.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,2,5]]},"abstract":"\n Background<\/jats:title>\n \n Monocular vision loss, attributed to either central retinal artery occlusion (\n CRAO<\/jats:styled-content>\n ), branch retinal artery occlusion (\n BRAO<\/jats:styled-content>\n ), or ocular ischemic syndrome (\n OIS<\/jats:styled-content>\n ), is thought to be associated with an increased prevalence of cerebral infarcts. However, there is a paucity of data substantiating this. We aimed to investigate this relationship in a Canadian center and further understand the importance of associated internal carotid artery stenosis in potential clinical decision making.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We performed a retrospective cohort study at a comprehensive stroke center of patients presenting initially with\n CRAO<\/jats:styled-content>\n ,\n BRAO<\/jats:styled-content>\n , or\n OIS<\/jats:styled-content>\n to a centralized ophthalmology center over a 5\u2010year period. Patients were followed for 3\u00a0years for the occurrence of a hemispheric stroke. We identified 83 affected eyes, with 31\n CRAO<\/jats:styled-content>\n , 35\n BRAO<\/jats:styled-content>\n , and 17\n OIS<\/jats:styled-content>\n patients. Before ocular diagnosis, 32.3%, 11.4%, and 41.2% of\n CRAO<\/jats:styled-content>\n ,\n BRAO<\/jats:styled-content>\n , and\n OIS<\/jats:styled-content>\n patients, respectively, experienced a symptomatic stroke. Of the remaining patients, 4.8%, 12.9%, and 40%, respectively, suffered a hemispheric stroke within 3\u00a0years of ocular diagnosis. Logistic regressions suggested that for\n CRAO<\/jats:styled-content>\n and\n BRAO<\/jats:styled-content>\n patients together, the degree of ipsilateral internal carotid artery stenosis is unable to predict the occurrence of a stroke (\n P<\/jats:italic>\n =0.18), whereas our model correctly predicted a stroke in 82.4% of\n OIS<\/jats:styled-content>\n patients (\n P<\/jats:italic>\n =0.005).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n CRAO<\/jats:styled-content>\n ,\n BRAO<\/jats:styled-content>\n , and\n OIS<\/jats:styled-content>\n are associated with significantly increased symptomatic stroke rates. Degree of ipsilateral internal carotid artery stenosis may not be useful in risk stratification for these patients, suggesting that they should be triaged appropriately for stroke risk\u2010factor management, independent of internal carotid artery stenosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.010509","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T10:00:22Z","timestamp":1549274422000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Risk of Stroke in Patients With Ocular Arterial Occlusive Disorders: A Retrospective Canadian Study"],"prefix":"10.1161","volume":"8","author":[{"given":"Michael B.","family":"Avery","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itay","family":"Magal","sequence":"additional","affiliation":[{"name":"Southern Alberta Eye Centre University of Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Kherani","sequence":"additional","affiliation":[{"name":"Southern Alberta Eye Centre University of Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alim P.","family":"Mitha","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of Calgary Alberta Canada"},{"name":"Department of Radiology University of Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000152"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa002994"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.07.054"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.03.006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23597"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.01.033"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-011-0053-1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.10.1446"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.07.018"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.302.6775.499"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.03.046"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010828"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.05.044"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.03.020"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.22608\/APO.201690"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8702-x"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.118.010509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:34:32Z","timestamp":1715600072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.118.010509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,5]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,2,5]]}},"alternative-id":["10.1161\/JAHA.118.010509"],"URL":"https:\/\/doi.org\/10.1161\/jaha.118.010509","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,5]]},"assertion":[{"value":"2018-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e010509"}}