{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:51:13Z","timestamp":1791409873036,"version":"4.3.3"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,6,18]]},"abstract":"\n Background<\/jats:title>\n \n Significant coronary artery disease has a well\u2010known association with long\u2010term adverse cardiovascular events. In this study, we aimed to evaluate its association with long\u2010term major adverse clinical events (\n MACE<\/jats:styled-content>\n ) up to 5\u00a0years in patients who presented with chest pain without significant\n coronary artery disease<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A total of 5890 subjects with chest pain without significant\n coronary artery disease<\/jats:styled-content>\n were prospectively enrolled in this study. The mean follow\u2010up duration was 3.4\u00a0years. Multivariable Cox proportional hazards regression analysis was performed for assessing the independent risk factors for\n MACE<\/jats:styled-content>\n or sustained angina pectoris.\n MACE<\/jats:styled-content>\n was defined as the composite of total death, myocardial infarction, coronary revascularization, stroke, and hospitalization because of heart failure. Ninety\u2010one (2.2%) patients developed\n MACE<\/jats:styled-content>\n , and 309 (8.1%) patients developed sustained\n angina pectoris<\/jats:styled-content>\n , both within 5\u00a0years. In multivariable Cox proportional hazards regression analysis, the risk of\n MACE<\/jats:styled-content>\n was significantly associated with age (per 5\u00a0years; hazard ratio [\n HR<\/jats:styled-content>\n ], 1.44; 95%\n CI<\/jats:styled-content>\n , 1.30\u20131.60) and insignificant coronary stenosis (30%\u201370%;\n HR,<\/jats:styled-content>\n 2.03; 95%\n CI;<\/jats:styled-content>\n 1.28\u20133.21). The risk of sustained\n angina pectoris<\/jats:styled-content>\n was significantly associated with age (per 5\u00a0years;\n HR,<\/jats:styled-content>\n 1.05; 95%\n CI,<\/jats:styled-content>\n 1.01\u20131.11), dyslipidemia (\n HR,<\/jats:styled-content>\n 1.34; 95%\n CI<\/jats:styled-content>\n , 1.06\u20131.70),\n insignificant coronary stenosis<\/jats:styled-content>\n (\n HR,<\/jats:styled-content>\n 2.54; 95%\n CI<\/jats:styled-content>\n , 1.94\u20133.31), coronary artery spasm (HR, 1.42; 95%\n CI<\/jats:styled-content>\n , 1.11\u20131.80), and myocardial bridge (HR, 1.37; 95%\n CI<\/jats:styled-content>\n , 1.04\u20131.81).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In patients without significant\n CAD<\/jats:styled-content>\n , aging and\n insignificant coronary stenosis<\/jats:styled-content>\n have a strong association with future long\u2010term\n MACE<\/jats:styled-content>\n . Also, aging, dyslipidemia,\n insignificant coronary stenosis<\/jats:styled-content>\n ,\n coronary artery spasm,<\/jats:styled-content>\n and\n myocardial bridge<\/jats:styled-content>\n are strongly associated with future\n angina pectoris<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.010541","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T09:00:19Z","timestamp":1560330019000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":76,"title":["Association of Major Adverse Cardiac Events up to 5\u00a0Years in Patients With Chest Pain Without Significant Coronary Artery Disease in the Korean Population"],"prefix":"10.1161","volume":"8","author":[{"given":"Byoung Geol","family":"Choi","sequence":"first","affiliation":[{"name":"Research Institute of Health Sciences Korea University College of Health Science Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Woon","family":"Rha","sequence":"additional","affiliation":[{"name":"Korea Cardiovascular Center Korea University Guro Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Gyu","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Medicine Korea University Graduate School Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Ung","family":"Choi","sequence":"additional","affiliation":[{"name":"Korea Cardiovascular Center Korea University Guro Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Institute of Health Sciences Korea University College of Health Science Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhng Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Health and Safety Convergence Science Korea University Graduate School Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000047041.66447.29"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2008.01.001"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.01.026"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.05.030"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004096"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.03.081"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003217"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000000558"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.050"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.07.001"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2011.01.012"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2012.12.008"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.06.1324"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.02.021"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014996"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-08-0774"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-66-0098"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.118.010541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:50:48Z","timestamp":1715601048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.118.010541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,18]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,6,18]]}},"alternative-id":["10.1161\/JAHA.118.010541"],"URL":"https:\/\/doi.org\/10.1161\/jaha.118.010541","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,18]]},"assertion":[{"value":"2018-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e010541"}}