{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:29:54Z","timestamp":1758637794991,"version":"3.41.2"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,2,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We aimed to clarify associations between prior anticoagulation and short\u2010 or long\u2010term clinical outcomes in ischemic stroke or transient ischemic attack patients with nonvalvular atrial fibrillation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 1189 ischemic stroke or transient ischemic attack patients with nonvalvular atrial fibrillation who were hospitalized within 7\u00a0days after onset were analyzed. Of these, 813 patients (68.4%) received no prior anticoagulation, 310 (26.1%) received prior warfarin treatment with an international normalized ratio (\n              <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content>\n              ) &lt;2 on admission, 28 (2.4%) received prior warfarin treatment with an\n              <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content>\n              \u22652 on admission, and the remaining 38 (3.2%) received prior direct oral anticoagulant treatment. Prior warfarin treatment was associated with a lower risk of death or disability at 3\u00a0months compared with no prior anticoagulation (\n              <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content>\n              &lt;2: adjusted odds ratio: 0.58; 95% CI, 0.42\u20130.81;\n              <jats:italic>P<\/jats:italic>\n              =0.001;\n              <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content>\n              \u22652: adjusted odds ratio: 0.40; 95% CI, 0.16\u20130.97;\n              <jats:italic>P<\/jats:italic>\n              =0.043) but was not associated with a lower risk of death or disability at 2\u00a0years. Prior warfarin treatment with an\n              <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content>\n              \u22652 on admission was associated with a higher risk of ischemic events within 2\u00a0years compared with no prior anticoagulation (adjusted hazard ratio: 2.94; 95% CI, 1.20\u20136.15;\n              <jats:italic>P<\/jats:italic>\n              =0.021).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Prior warfarin treatment was associated with a lower risk of death or disability at 3\u00a0months but was not associated with a lower risk of death or disability at 2\u00a0years in ischemic stroke or transient ischemic attack patients with nonvalvular atrial fibrillation. Prior warfarin treatment with an\n              <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content>\n              \u22652 on admission was associated with a higher risk of ischemic events within 2\u00a0years.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              01581502.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.010593","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T10:02:40Z","timestamp":1548756160000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Prior Anticoagulation and Short\u2010 or Long\u2010Term Clinical Outcomes in Ischemic Stroke or Transient Ischemic Attack Patients With Nonvalvular Atrial Fibrillation"],"prefix":"10.1161","volume":"8","author":[{"given":"Keisuke","family":"Tokunaga","sequence":"first","affiliation":[{"name":"Department of Cerebrovascular Medicine National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Itabashi","sequence":"additional","affiliation":[{"name":"Department of Stroke Neurology Kohnan Hospital Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamagami","sequence":"additional","affiliation":[{"name":"Division of Stroke Care Unit National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Todo","sequence":"additional","affiliation":[{"name":"Department of Neurology Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohei","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine National Cerebral and Cardiovascular Center Suita 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