{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:33:23Z","timestamp":1791981203717,"version":"4.4.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,11,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              White matter hyperintensities (\n              <jats:styled-content style=\"fixed-case\">WMHs<\/jats:styled-content>\n              ) are commonly asymmetric between hemispheres but for unknown reasons. We investigated asymmetric\n              <jats:styled-content style=\"fixed-case\">WMHs<\/jats:styled-content>\n              associated with lacunar infarcts.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 267 consecutive patients with small first\u2010ever supratentorial infarcts (\u226420\u00a0mm) were included. None had a relevant vascular stenosis.\n              <jats:styled-content style=\"fixed-case\">WMH<\/jats:styled-content>\n              asymmetry was measured based on the hemispheric difference of a modified Scheltens scale score (\u22653 defined as asymmetric). We analyzed the association of the hemispheric\n              <jats:styled-content style=\"fixed-case\">WMH<\/jats:styled-content>\n              asymmetry with old silent lacunar infarcts or acute lacunar infarcts. We compared lesion frequency maps between groups and generated t\u2010statistics maps. The mean age of patients was 64\u00a0years, and 63% were men. Asymmetric\n              <jats:styled-content style=\"fixed-case\">WMH<\/jats:styled-content>\n              was more than 3\u2010fold as frequent (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) in the group with old silent lacunar infarcts (42%, 43\/102) than in the group without old silent lacunar infarcts (15%, 24\/165). In patients with left hemispheric dominance of\n              <jats:styled-content style=\"fixed-case\">WMHs<\/jats:styled-content>\n              , an acute lacunar infarct was more likely to be located in the left (versus right) hemisphere (74% versus 26%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). In patients with right hemispheric dominance of\n              <jats:styled-content style=\"fixed-case\">WMHs<\/jats:styled-content>\n              , an acute lacunar infarct was more likely to be located on the right (versus left) hemisphere (81% versus 19%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Mapping studies showed that the side of hemispheric dominance of\n              <jats:styled-content style=\"fixed-case\">WMHs<\/jats:styled-content>\n              was associated with acute and silent lacunes on the same side.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              These are the first data to show that asymmetric\n              <jats:styled-content style=\"fixed-case\">WMH<\/jats:styled-content>\n              s are associated with both old silent lacunar infarcts and acute lacunar infarcts ipsilateral to the greatest\n              <jats:styled-content style=\"fixed-case\">WMH<\/jats:styled-content>\n              burden. This suggests that the hemisphere with relatively large\n              <jats:styled-content style=\"fixed-case\">WMHs<\/jats:styled-content>\n              is more vulnerable to ischemia.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.010653","type":"journal-article","created":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T20:51:29Z","timestamp":1544993489000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Hemispheric Asymmetry of White Matter Hyperintensity in Association With Lacunar Infarction"],"prefix":"10.1161","volume":"7","author":[{"given":"Wi\u2010Sun","family":"Ryu","sequence":"first","affiliation":[{"name":"Korean Brain MRI Data Center Dongguk University Ilsan Hospital Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawid","family":"Schellingerhout","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Cancer Systems Imaging University of Texas M. D. Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Seung","family":"Ahn","sequence":"additional","affiliation":[{"name":"Korean Brain MRI Data Center Dongguk University Ilsan Hospital Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Korean Brain MRI Data Center Dongguk University Ilsan Hospital Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun\u2010Sik","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology Ilsan Paik Hospital Inje University Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Wuk","family":"Jeong","sequence":"additional","affiliation":[{"name":"Korean Brain MRI Data Center Dongguk University Ilsan Hospital Goyang 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