{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:20:33Z","timestamp":1791231633933,"version":"4.1.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,12,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Data regarding long\u2010term outcome of patients with thromboangiitis obliterans are lacking and most series come from India and Japan. In this study, we assess long\u2010term outcome and prognostic factors in a large cohort of thromboangiitis obliterans.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Retrospective multicenter study of characteristics and outcomes of 224 thromboangiitis obliterans patients fulfilling Papa's criteria were analyzed. Factors associated with vascular events and amputations were identified. The median age at diagnosis was 38.5 (32\u201346) years, 51 (23.8%) patients were female, and 81.7% were whites. After a mean follow\u2010up of 5.7\u00a0years, vascular events were observed in 58.9%, amputations in 21.4%, and death in 1.4%. The 5\u2010, 10\u2010, and 15\u2010year vascular event\u2010free survival and amputation\u2010free survival were 41% and 85%, 23% and 74%, and 19% and 66%, respectively. Ethnic group (nonwhite) (hazard ratio 2.35 [1.30\u20134.27]\n              <jats:italic>P<\/jats:italic>\n              =0.005) and limb infection at diagnosis (hazard ratio 3.29 [1.02\u201310.6]\n              <jats:italic>P<\/jats:italic>\n              =0.045) were independent factors of vascular event\u2010free survival. Factor associated with amputation was limb infection (hazard ratio 12.1 [3.5\u201342.1],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Patients who stopped their tobacco consumption had lower risk of amputation (\n              <jats:italic>P<\/jats:italic>\n              =0.001) than those who continued.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">This nationwide study shows that 34% of thromboangiitis obliterans patients will experience an amputation within 15\u00a0years from diagnosis. We identified high\u2010risk patients for vascular complications and amputations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.010677","type":"journal-article","created":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T10:01:01Z","timestamp":1543658461000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Long\u2010Term Outcome and Prognostic Factors of Complications in Thromboangiitis Obliterans (Buerger's Disease): A Multicenter Study of 224 Patients"],"prefix":"10.1161","volume":"7","author":[{"given":"Alexandre","family":"Le Joncour","sequence":"first","affiliation":[{"name":"UPMC Univ Paris 06 UMR 7211, and Inflammation\u2010Immunopathology\u2010Biotherapy Department (DHU i2B) Sorbonne Universit\u00e9s Paris France"},{"name":"UMR_S 959 INSERM Paris France"},{"name":"Department of Internal Medicine and Clinical Immunology AP\u2010HP Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"},{"name":"Centre national de r\u00e9f\u00e9rence des maladies Autoimmunes Syst\u00e9miques rares Centre National de R\u00e9f\u00e9rence Des Maladies Autoinflammatoires et de l'Amylose France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Soudet","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique CHU Lille Lille France"},{"name":"Centre National de R\u00e9f\u00e9rence des Maladies Autoimmunes et Syst\u00e9miques Rares (Scl\u00e9rodermie) France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axelle","family":"Dupont","sequence":"additional","affiliation":[{"name":"Service de Biostatistique et Information m\u00e9dicale APHP H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Espitia","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine interne CHU de Nantes Nantes 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Emmerich","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine and Cardiology University Hospital Hotel Dieu University Paris\u2010Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Cacoub","sequence":"additional","affiliation":[{"name":"UPMC Univ Paris 06 UMR 7211, and Inflammation\u2010Immunopathology\u2010Biotherapy Department (DHU i2B) Sorbonne Universit\u00e9s Paris France"},{"name":"UMR_S 959 INSERM Paris France"},{"name":"Department of Internal Medicine and Clinical Immunology AP\u2010HP Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"},{"name":"Centre national de r\u00e9f\u00e9rence des maladies Autoimmunes Syst\u00e9miques rares Centre National de R\u00e9f\u00e9rence Des Maladies Autoinflammatoires et de l'Amylose 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