{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:01:04Z","timestamp":1789768864693,"version":"4.0.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,5,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In shunt\u2010dependent, single\u2010ventricle patients, mortality remains high in the interstage period between discharge after neonatal surgery and stage 2 operation. We sought to evaluate the impact of our infant single\u2010ventricle management and monitoring program (\n                      <jats:styled-content style=\"fixed-case\">ISVMP<\/jats:styled-content>\n                      ) on interstage mortality and stage 2 outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      This retrospective single\u2010center cohort study compared patients enrolled in\n                      <jats:styled-content style=\"fixed-case\">ISVMP<\/jats:styled-content>\n                      at hospital discharge with historical controls. The relationship of\n                      <jats:styled-content style=\"fixed-case\">ISVMP<\/jats:styled-content>\n                      to interstage mortality was determined with a bivariate probit model for the joint modeling of both groups, using an instrumental variables approach. We included 166\n                      <jats:styled-content style=\"fixed-case\">ISVMP<\/jats:styled-content>\n                      participants (December 1, 2010, to June 30, 2015) and 168 controls (January 1, 2007, to November 30, 2010). The groups did not differ by anatomy, gender, race, or genetic syndrome. Mortality was lower in the\n                      <jats:styled-content style=\"fixed-case\">ISVMP<\/jats:styled-content>\n                      group (5.4%) versus controls (13%). An\n                      <jats:styled-content style=\"fixed-case\">ISVMP<\/jats:styled-content>\n                      infant compared with a historical control had an average 29% lower predicted probability of interstage death (adjusted probability: \u22120.29; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , \u22120.52 to \u22120.057;\n                      <jats:italic>P<\/jats:italic>\n                      =0.015). On stratified analysis, mortality was lower in the hypoplastic left heart syndrome subgroup undergoing Norwood operation (4\/84 [4.8%] versus 12\/90 [14%],\n                      <jats:italic>P<\/jats:italic>\n                      =0.03) but not in those with initial palliation of shunt only (\n                      <jats:italic>P<\/jats:italic>\n                      =0.90).\n                      <jats:styled-content style=\"fixed-case\">ISVMP<\/jats:styled-content>\n                      participants were younger at the time of the stage 2 operation (138\u00a0versus 160\u00a0days,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), with no difference in postoperative mortality or length of stay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In this single\u2010center study, we report significantly lower interstage mortality for participants with hypoplastic left heart syndrome enrolled in\n                      <jats:styled-content style=\"fixed-case\">ISVMP<\/jats:styled-content>\n                      . Younger age at stage 2 operation was not associated with postoperative mortality or longer length of stay.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.118.010783","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T12:35:37Z","timestamp":1558442137000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Association of a Home Monitoring Program With Interstage and Stage 2 Outcomes"],"prefix":"10.1161","volume":"8","author":[{"given":"Monique M.","family":"Gardner","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mercer\u2010Rosa","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics The Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Faerber","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Children's Hospital of Philadelphia Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"DiLorenzo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics New York Presbyterian\/Morgan Stanley Children's Hospital Columbia University Irving Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E.","family":"Bates","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics and Communicable Diseases C.S. Mott Children's Hospital University of Michigan Medical School Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyson","family":"Stagg","sequence":"additional","affiliation":[{"name":"Division of Cardiology The Children's Hospital of Philadelphia, and The University of Pennsylvania School of Nursing Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shobha S.","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics The Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Szwast","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics The Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania Philadelphia 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