{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:26:27Z","timestamp":1788175587621,"version":"build-2803163510"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,3,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Hypertension is assumed to be asymptomatic. Yet, clinically significant nocturia (\u22652 nightly voids) constitutes a putative symptom of uncontrolled hypertension. Black men with hypertension may be prone to nocturia because of blunted nocturnal blood pressure (\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              ) dipping, diuretic drug use for hypertension, and comorbidity that predisposes to nocturia. Here, we test the hypothesis that nocturia is a common and potentially reversible symptom of uncontrolled hypertension in black men.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We determined the strength of association between nocturia (\u22652 nightly voids) and high\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              (\u2265135\/85\u00a0mm\u00a0Hg) by conducting in\u2010person health interviews and measuring\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              with an automated monitor in a large community\u2010based sample of black men in their barbershops. Because nocturia is prevalent and steeply age\u2010dependent after age 50\u00a0years, we studied men aged 35 to 49\u00a0years. Among 1673 black men (mean age, 43\u00b14\u00a0years [\n              <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n              ]), those with hypertension were 56% more likely than men with normotension to have nocturia after adjustment for diabetes mellitus and sleep apnea (adjusted odds ratio, 1.56; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.25\u20131.94 [\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001]). Nocturia prevalence varied by hypertension status, ranging from 24% in men with normotension to 49% in men whose hypertension was medically treated but uncontrolled. Men with untreated hypertension were 39% more likely than men with normotension to report nocturia (\n              <jats:italic>P<\/jats:italic>\n              =0.02), whereas men whose hypertension was treated and controlled were no more likely than men with normotension to report nocturia (\n              <jats:italic>P<\/jats:italic>\n              =0.69).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Uncontrolled hypertension was an independent determinant of clinically important nocturia in a large cross\u2010sectional community\u2010based study of non\u2010Hispanic black men aged 35 to 49\u00a0years.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unqiue identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              02321618.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.010794","type":"journal-article","created":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T10:00:18Z","timestamp":1551520818000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Nocturia as an Unrecognized Symptom of Uncontrolled Hypertension in Black Men Aged 35 to 49\u00a0Years"],"prefix":"10.1161","volume":"8","author":[{"given":"Ronald G.","family":"Victor","sequence":"first","affiliation":[{"name":"Smidt Heart Institute at Cedars\u2010Sinai Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomathematics David Geffen School of Medicine at UCLA Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciantel A.","family":"Blyler","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute at Cedars\u2010Sinai Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O'Neil R.","family":"Mason","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute at Cedars\u2010Sinai Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Cindy","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biomathematics David Geffen School of Medicine at UCLA Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma Priscilla B.","family":"Moy","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute at Cedars\u2010Sinai Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A.","family":"Rashid","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute at Cedars\u2010Sinai Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P.","family":"Weiss","sequence":"additional","affiliation":[{"name":"The State University of New York Downstate Brooklyn NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Handler","sequence":"additional","affiliation":[{"name":"Kaiser\u2010Permanente Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Brettler","sequence":"additional","affiliation":[{"name":"Kaiser\u2010Permanente Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Sagisi","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute at Cedars\u2010Sinai Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Rader","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute at Cedars\u2010Sinai Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Elashoff","sequence":"additional","affiliation":[{"name":"Department of Biomathematics David Geffen School of Medicine at UCLA Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"e_1_3_2_3_2","first-page":"e13","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton PK","year":"2017","unstructured":"Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, DePalma SM, Gidding S, Jamerson KA, Jones DW, MacLaughlin EJ, Muntner P, Ovbiagele B, Smith SC Jr, Spencer CC, Stafford RS, Taler SJ, Thomas RJ, Williams KA Sr, Williamson JD, Wright JT Jr. 2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. 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