{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:15:37Z","timestamp":1790255737892,"version":"4.1.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,6,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Little is known about the relationship between echocardiographic abnormalities and outcome among patients with acute stroke. We investigated the pattern and association of baseline echocardiographic variables with 1\u2010month disability and mortality among patients with stroke in the\n              <jats:styled-content style=\"fixed-case\">SIREN<\/jats:styled-content>\n              (Stroke Investigative Research and Education Network) study.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We enrolled and followed up consecutive 1020 adult patients with acute stroke with baseline transthoracic echocardiography from west Africa. To explore the relationship between echocardiographic variables and 1\u2010month disability (using modified Rankin scale &gt;3) and fatality, regression models were fitted. Relative risks were computed with 95% CIs. The participants comprised 60% men with a mean age of 59.2\u00b114.6\u00a0years. Ischemic stroke was associated with smaller aortic root diameter (30.2 versus 32.5,\n              <jats:italic>P<\/jats:italic>\n              =0.018) and septal (16.8 versus 19.1,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and posterior wall thickness at systole (18.9 versus 21.5,\n              <jats:italic>P<\/jats:italic>\n              =0.004). Over 90% of patients with stroke had abnormal left ventricular (LV) geometry with eccentric hypertrophy predominating (56.1%). Of 13 candidate variables investigated, only baseline abnormal\n              <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n              geometry (concentric hypertrophy) was weakly associated with 1\u2010month disability (unadjusted relative risk, 1.80; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 0.97\u20135.73). Severe\n              <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n              systolic dysfunction was significantly associated with increased 1\u2010month mortality (unadjusted relative risk, 3.05; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.36\u20136.83).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Nine of 10 patients with acute stroke had abnormal\n              <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n              geometry and a third had systolic dysfunction. Severe\n              <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n              systolic dysfunction was significantly associated with 1\u00a0month mortality. Larger studies are required to establish the independent effect and unravel predictive accuracy of this association.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.010814","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T09:00:19Z","timestamp":1559206819000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Echocardiographic Abnormalities and Determinants of 1\u2010Month Outcome of Stroke Among West Africans in the SIREN Study"],"prefix":"10.1161","volume":"8","author":[{"given":"Abiodun M.","family":"Adeoye","sequence":"first","affiliation":[{"name":"Center for Genomic and Precision Medicine University of Ibadan Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Ovbiagele","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Francisco 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