{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:59:48Z","timestamp":1790283588168,"version":"4.1.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,12,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Recent randomized controlled trials show benefit of thrombectomy for large vessel occlusion in stroke. Real\u2010world data aid in assessing reproducibility of outcomes outside of clinical trials. The Trevo Retriever Registry is a multicenter, international, prospective study designed to assess outcomes in a large cohort of patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The Trevo Registry is a prospective database of patients with large vessel occlusion treated with the Trevo device as the first device. The primary end point is revascularization based on modified Thrombolysis in Cerebral Infarction score and secondary end points include 90\u2010day modified Rankin Scale, 90\u2010day mortality, neurological deterioration at 24\u00a0hours, and device\/procedure related adverse events. Year 2008 patients were enrolled at 76 centers in 12 countries. Median admission National Institutes of Health Stroke Scale was 16 (interquartile range, 11\u201320). Occlusion sites were internal carotid artery (17.8%), middle cerebral artery (73.5%), posterior circulation (7.1%), and distal vascular locations (1.6%). A modified Thrombolysis in Cerebral Infarction 2b or 3 was achieved in 92.8% (95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              91.6, 93.9) of procedures, with 55.3% (95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              53.1, 57.5) of patients achieving modified Rankin Scale \u22642 at 3\u00a0months. Patients meeting revised 2015 American Heart Association criteria for thrombectomy had a 59.7% (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 56.0; 63.4) modified Rankin Scale 0 to 2 at 3\u00a0months, whereas 51.4% treated outside of American Heart Association criteria had modified Rankin Scale 0 to 2. 51.4% (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 49.6, 55.4). Symptomatic intracranial hemorrhage rate was 1.7% (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.2, 2.4).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The Trevo Retriever Registry represents real\u2010world data with stent retriever. The registry demonstrates similar reperfusion rates and outcomes in the community compared with rigorous centrally adjudicated clinical trials. Future subgroup analysis of this cohort will assist in identifying areas of future research.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              02040259.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.010867","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T10:00:58Z","timestamp":1544436058000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Trevo 2000: Results of a Large Real\u2010World Registry for Stent Retriever for Acute Ischemic Stroke"],"prefix":"10.1161","volume":"7","author":[{"given":"Mandy J.","family":"Binning","sequence":"first","affiliation":[{"name":"Department of Neurosciences Drexel Neurosciences Institute Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Bartolini","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology La Piti\u00e9 Salp\u00e9tri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaise","family":"Baxter","sequence":"additional","affiliation":[{"name":"Department of Radiology Erlanger Hospital Chattanooga TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Budzik","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology Riverside Methodist Hospital\/Ohio Health Research Institute Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joey","family":"English","sequence":"additional","affiliation":[{"name":"Department of Neurology California Pacific Medical Center San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Wellstar Health System Atlanta 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Stryker Neurovascular Fremont CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Veznedaroglu","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Drexel Neurosciences Institute Philadelphia 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