{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:27:38Z","timestamp":1790162858528,"version":"4.1.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Among people with lower extremity peripheral artery disease, obesity is associated with faster functional decline than normal weight. The association of weight loss with functional decline in peripheral artery disease is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Adults with an ankle\u2010brachial index &lt;0.90 were identified from Chicago\u2010area hospitals in 2002\u20132004. Weight and 6\u2010minute walk distance were measured annually. Weight change categories were weight loss or gain (\u22655 pounds\/year at \u22651 visit) or stable (weight change &lt;5 pounds at each visit). Participants reported whether weight loss was \u201cintentional\u201d or \u201cunintentional.\u201d Calf muscle area was measured with computed tomography every 2\u00a0years. Associations of weight change with changes in calf muscle area and 6\u2010minute walk distance were analyzed using mixed\u2010effects models and adjusted for age, body mass index, ankle\u2010brachial index, physical activity, and other confounders. Among 389 participants, mean ankle\u2010brachial index was 0.63\u00b10.16, mean age was 74.5\u00b17.8, and mean body mass index was 28.1\u00b15.1\u00a0kg\/m\n              <jats:sup>2<\/jats:sup>\n              . Over 3.23\u00b11.37\u00a0years, muscle area declined more in adults with intentional weight loss versus stable or gain (pair\u2010wise comparisons,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Intentional weight loss was associated with less annual decline in 6\u2010minute walk distance than weight gain (intentional loss, 3.7\u00a0m; stable, \u201314.0\u00a0m; gain, \u221228.5\u00a0m; unintentional loss, \u221220.8\u00a0m; pair\u2010wise comparison intentional loss versus gain,\n              <jats:italic>P<\/jats:italic>\n              =0.003).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Despite a greater loss of calf muscle area, adults with peripheral artery disease who intentionally lost \u22655 pounds experienced less functional decline than those who gained weight. A randomized trial is needed to establish whether benefits of weight loss in peripheral artery disease outweigh potential adverse effects.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.010890","type":"journal-article","created":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T09:08:05Z","timestamp":1561799285000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease"],"prefix":"10.1161","volume":"8","author":[{"given":"Tamar S.","family":"Polonsky","sequence":"first","affiliation":[{"name":"Department of Medicine University of Chicago Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Health Research and Policy Stanford University Palo Alto CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia A.","family":"Bazzano","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Tulane School of Public Health and Tropical Medicine New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Criqui","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Public Health University of California at San Diego San Diego CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"Division of Intramural Research National Institute on Aging Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack M.","family":"Guralnik","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health University of Maryland School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina R.","family":"Kibbe","sequence":"additional","affiliation":[{"name":"Department of Surgery University of North Carolina Chapel Hill NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiaan","family":"Leeuwenburgh","sequence":"additional","affiliation":[{"name":"Department of Aging and Geriatric Research Institute on Aging University of Florida Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Sufit","sequence":"additional","affiliation":[{"name":"Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr228"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.03.065"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp195"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.06.011"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.0538"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-1286"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.09.006"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.10.105"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000155219"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.01.048"},{"key":"e_1_3_1_12_2","first-page":"8","article-title":"Predictors of improved walking after a supervised walking exercise program in men and women with peripheral artery disease","volume":"2016","author":"Gardner AW","year":"2016","unstructured":"Gardner AW, Parker DE, Montgomery PS. 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