{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:29:11Z","timestamp":1784773751589,"version":"3.55.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,5,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Decreased uterine blood flow is known to contribute to pregnancy complications such as gestational hypertension and preeclampsia. Previously, we showed that the loss of regulator of G protein signaling 2 (\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              2), a\n              <jats:styled-content style=\"fixed-case\">GTP<\/jats:styled-content>\n              ase activating protein for G\n              <jats:sub>q\/11<\/jats:sub>\n              and G\n              <jats:sub>i\/o<\/jats:sub>\n              class G proteins, decreases uterine blood flow in the nonpregnant state in mice. Here, we examined the effects of the absence of\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              2 and 5 on uterine blood flow and uterine vascular structure and function at early, mid, and late gestation, as well as peripartum period in mice.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Abdominal Doppler ultrasonography was performed on adult female wild\u2010type,\n              <jats:italic>\n                Rgs2\n                <jats:sup>\u2212\/\u2212<\/jats:sup>\n              <\/jats:italic>\n              , and\n              <jats:italic>\n                Rgs5\n                <jats:sup>\u2212\/\u2212<\/jats:sup>\n              <\/jats:italic>\n              mice at pre\u2010pregnancy, gestational days 10, 15, and 18, and postpartum day 3. Uterine artery structure and function were also assessed by vessel myograph studies. At mid\u2010pregnancy, uterine blood flow decreased in both\n              <jats:italic>\n                Rgs2\n                <jats:sup>\u2212\/\u2212<\/jats:sup>\n              <\/jats:italic>\n              and\n              <jats:italic>\n                Rgs5\n                <jats:sup>\u2212\/\u2212<\/jats:sup>\n              <\/jats:italic>\n              mice, whereas resistive index increased only in\n              <jats:italic>\n                Rgs2\n                <jats:sup>\u2212\/\u2212<\/jats:sup>\n              <\/jats:italic>\n              mice. In uterine arteries from wild\u2010type mice,\n              <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n              expression of\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              2 and 4 increased, whereas\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              5 expression remained elevated at mid\u2010pregnancy. These changes in gene expression were unique to uterine arteries because they were absent in mesenteric arteries and the aorta of wild\u2010type mice. In\n              <jats:italic>\n                Rgs2\n                <jats:sup>\u2212\/\u2212<\/jats:sup>\n              <\/jats:italic>\n              mice, uterine artery medial cross\u2010sectional area and G protein\u2013coupled receptor\u2010mediated vasoconstriction increased in mid\u2010pregnancy, implicating a role for\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              2 in structural and functional remodeling of uterine arteries during pregnancy. In contrast,\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              5 absence increased vasoconstriction only in the peripartum period.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              These data together indicate that\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              2 plays a critical role in the structural and functional remodeling of uterine arteries to impact uterine blood flow during pregnancy. Targeting the signaling pathway regulated by\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              2 may therefore be a therapeutic strategy for ameliorating utero\u2010placental perfusion disorders during pregnancy.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.010917","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T09:02:14Z","timestamp":1556528534000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Regulator of G Protein Signaling 2 Facilitates Uterine Artery Adaptation During Pregnancy in Mice"],"prefix":"10.1161","volume":"8","author":[{"given":"Jennifer N.","family":"Koch","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Physiology Drexel University College of Medicine Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby A.","family":"Dahlen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology Drexel University College of Medicine Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Owens","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology Drexel University College of Medicine Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Osei\u2010Owusu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology Drexel University College of Medicine Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90834-T"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00033.2008"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57303-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.6.1669"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)58400-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1495190"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000356171"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1660777"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19116"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13939.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90785-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/383172a0"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/10606820308244"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14389"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00331"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa5038"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-15-28"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12692"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.220414397"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01889-07"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2013.09.026"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132594"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00601.2013"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.04.044"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-9-18"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/stke.3702007pe2"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.3.7367"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.300142"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2015.02.003"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2015.02.001"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15598"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0420479"},{"key":"e_1_3_2_34_2","first-page":"25","article-title":"The renin\u2010angiotensin system in pregnancy and parturition","volume":"15","author":"Alhenc\u2010Gelas F","year":"1986","unstructured":"Alhenc\u2010Gelas F, Tache A, Saint\u2010Andre JP, Milliez J, Sureau C, Corvol P, Menard J. 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