{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:13:51Z","timestamp":1788225231171,"version":"build-2803163510"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,5,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The association between time to reperfusion and clinical outcome is well known in anterior circulation strokes, whereas the impact of main time metrics remains unknown in posterior circulation strokes. We investigated the clinical effect of different time intervals from symptom onset to reperfusion on the 90\u2010day clinical outcome in acute ischemic stroke patients with basilar artery occlusion, and especially in the subset population presenting a low stroke volume on baseline diffusion\u2010weighted imaging.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We studied patients included in the prospective, multicenter, observational\n              <jats:styled-content style=\"fixed-case\">ETIS<\/jats:styled-content>\n              (Endovascular Treatment in Ischemic Stroke) registry who had had basal artery occlusion and had achieved successful reperfusion (modified Thrombolysis In Cerebral Infarction 2b\u20103). Three time intervals (onset to reperfusion, onset to imaging, and imaging to reperfusion) were considered in all patients and separately in patients with pc\u2010\n              <jats:styled-content style=\"fixed-case\">ASPECTS<\/jats:styled-content>\n              (posterior\u2010circulation Alberta Stroke Program Early Computed Tomography Score) &lt;8 and \u22658 on baseline diffusion\u2010weighted imaging. The primary end point was good outcome defined as 90\u2010day modified Rankin Scale scores of 0 to 2. Among the 95 included patients, 38 (40%) achieved a good outcome. In all patients, no significant association was found between the different time intervals and outcome. In patients evaluated with diffusion\u2010weighted imaging (n=61) at baseline, a significant negative association was found between imaging\u2010to\u2010reperfusion time for patients with pc\u2010\n              <jats:styled-content style=\"fixed-case\">ASPECTS<\/jats:styled-content>\n              &lt;8 (adjusted odds ratio=0.4 per 30\u2010minute increase; 95% CI 0.18\u20100.85;\n              <jats:italic>P<\/jats:italic>\n              =0.02) compared with those with pc\u2010\n              <jats:styled-content style=\"fixed-case\">ASPECTS<\/jats:styled-content>\n              \u22658.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In patients with basilar artery occlusion and pc\u2010\n              <jats:styled-content style=\"fixed-case\">ASPECTS<\/jats:styled-content>\n              &lt;8 at baseline diffusion\u2010weighted imaging, clinical outcome is highly dependent on the time from imaging to reperfusion, which suggests that rapid endovascular reperfusion should be performed after imaging in these patients.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.010962","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T09:04:19Z","timestamp":1557392659000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Rapid Successful Reperfusion of Basilar Artery Occlusion Strokes With Pretreatment Diffusion\u2010Weighted Imaging Posterior\u2010Circulation ASPECTS &lt;8 Is Associated With Good Outcome"],"prefix":"10.1161","volume":"8","author":[{"given":"Morgan","family":"Guillaume","sequence":"first","affiliation":[{"name":"Stroke Unit Department of Neurology University Hospital of Nancy 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