{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:24:31Z","timestamp":1792589071556,"version":"4.5.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,1,22]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Central arterial stiffening and increased pulsatility, with consequent cerebral hypoperfusion, may result in structural brain damage and cognitive impairment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We analyzed a cross\u2010sectional sample of\n              <jats:styled-content style=\"fixed-case\">ARIC<\/jats:styled-content>\n              \u2010\n              <jats:styled-content style=\"fixed-case\">NCS<\/jats:styled-content>\n              (Atherosclerosis Risk in Communities\u2013Neurocognitive Study) participants (aged 67\u201390\u00a0years, 60% women) with measures of cognition (n=3703) and brain magnetic resonance imaging (n=1255). Central arterial hemodynamics were assessed as carotid\u2010femoral pulse wave velocity and pressure pulsatility (central pulse pressure). We derived factor scores for cognitive domains. Brain\n              <jats:styled-content style=\"fixed-case\">magnetic resonance imaging<\/jats:styled-content>\n              using 3\u2010Tesla scanners quantified lacunar infarcts; cerebral microbleeds; and volumes of white matter hyperintensities, total brain, and the Alzheimer disease signature region. We used logistic regression, adjusted for demographics,\n              <jats:styled-content style=\"fixed-case\">apolipoprotein E<\/jats:styled-content>\n              \u025b4, heart rate, mean arterial pressure, and select cardiovascular risk factors, to estimate the odds of lacunar infarcts or cerebral microbleeds. Linear regression, additionally adjusted for intracranial volume, estimated the difference in log\u2010transformed volumes of\n              <jats:styled-content style=\"fixed-case\">white matter hyperintensities<\/jats:styled-content>\n              , total brain, and the\n              <jats:styled-content style=\"fixed-case\">Alzheimer disease<\/jats:styled-content>\n              signature region. We estimated the mean difference in cognitive factor scores across quartiles of carotid\u2010femoral pulse wave velocity or\n              <jats:styled-content style=\"fixed-case\">central pulse pressure<\/jats:styled-content>\n              using linear regression. Compared with participants in the lowest carotid\u2010femoral pulse wave velocity quartile, participants in the highest quartile of carotid\u2010femoral pulse wave velocity had a greater burden of\n              <jats:styled-content style=\"fixed-case\">white matter hyperintensities<\/jats:styled-content>\n              (\n              <jats:italic>P<\/jats:italic>\n              =0.007 for trend), smaller total brain volumes (\u221218.30\u00a0cm\n              <jats:sup>3<\/jats:sup>\n              ; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , \u221227.54 to \u22129.07 cm\n              <jats:sup>3<\/jats:sup>\n              ), and smaller\n              <jats:styled-content style=\"fixed-case\">Alzheimer disease<\/jats:styled-content>\n              signature region volumes (\u22121.48\u00a0cm\n              <jats:sup>3<\/jats:sup>\n              ; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , \u22122.27 to \u22120.68 cm\n              <jats:sup>3<\/jats:sup>\n              ). These participants also had lower scores in executive function\/processing speed (\u03b2=\u22120.04\n              <jats:italic>z<\/jats:italic>\n              score; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , \u22120.07 to \u22120.01\n              <jats:italic>z<\/jats:italic>\n              score) and general cognition (\u03b2=\u22120.09\n              <jats:italic>z<\/jats:italic>\n              score; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , \u22120.15 to \u22120.03\n              <jats:italic>z<\/jats:italic>\n              score). Similar results were observed for\n              <jats:styled-content style=\"fixed-case\">central pulse pressure<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Central arterial hemodynamics were associated with structural brain damage and poorer cognitive performance among older adults.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.011045","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T10:00:43Z","timestamp":1547632843000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":101,"title":["Central Arterial Stiffness Is Associated With Structural Brain Damage and Poorer Cognitive Performance: The ARIC Study"],"prefix":"10.1161","volume":"8","author":[{"given":"Priya","family":"Palta","sequence":"first","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health University of North Carolina at Chapel Hill NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Richey","family":"Sharrett","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins University Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingkai","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health University of North Carolina at Chapel Hill NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of North Carolina at Chapel Hill Chapel Hill NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kucharska\u2010Newton","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health University of North Carolina at Chapel Hill NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda C.","family":"Power","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Milken Institute School of Public Health George Washington University Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Deal","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins University Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford R.","family":"Jack","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Knopman","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Wright","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Griswold","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Education University of Texas at Austin TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Mosley","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Heiss","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health University of North Carolina at Chapel Hill NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000187"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.065"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00614.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05494"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2014.02.002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141416"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl254"},{"key":"e_1_3_2_9_2","unstructured":"Atherosclerosis Risk in Communities Study description. https:\/\/www2.cscc.unc.edu\/aric\/. Accessed October 25 2018"},{"key":"e_1_3_2_10_2","unstructured":"NHLBI Biologic Specimen and Data Respository Information Coordinating Center. https:\/\/biolincc.nhlbi.nih.gov\/home\/. Accessed October 25 2018."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115184"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007847"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821d753f"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpv079"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32832e94e7"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpv127"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182166e96"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010060"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000379"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu020"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318230e861"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.03.011"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141884"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00637.2017"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2015.12.022"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000443614"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.037"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06398"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.642264"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06610"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005259"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.126342"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000257998.33768.87"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr119"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2010.08.014"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3280895b55"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.093674"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.673533"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110034"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2011.0252"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.01.042"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003319712447888"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.118.011045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:18:03Z","timestamp":1715599083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.118.011045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,22]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,1,22]]}},"alternative-id":["10.1161\/JAHA.118.011045"],"URL":"https:\/\/doi.org\/10.1161\/jaha.118.011045","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,22]]},"assertion":[{"value":"2018-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e011045"}}