{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:35:37Z","timestamp":1792571737770,"version":"4.5.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,11,5]]},"abstract":"\n Background<\/jats:title>\n \n Left ventricular (\n LV<\/jats:styled-content>\n ) recovery in takotsubo syndrome (\n TTS<\/jats:styled-content>\n ) occurs over a wide\u2010ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for\n TTS<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n TTS<\/jats:styled-content>\n patients from the International Takotsubo Registry were included in this study. Cut\u2010off for early\n LV<\/jats:styled-content>\n recovery was determined to be 10\u00a0days after the acute event. Multivariable logistic regression was used to assess factors associated with the absence of early recovery. In\u2010hospital outcomes and 1\u2010year mortality were compared for patients with versus without early recovery. We analyzed 406 patients with comprehensive and serial imaging data regarding time to recovery. Of these, 191 (47.0%) had early\n LV<\/jats:styled-content>\n recovery and 215 (53.0%) demonstrated late\n LV<\/jats:styled-content>\n improvement. Patients without early recovery were more often male (12.6% versus 5.2%;\n P<\/jats:italic>\n =0.011) and presented more frequently with typical\n TTS<\/jats:styled-content>\n (76.3% versus 67.0%,\n P<\/jats:italic>\n =0.040). Cardiac and inflammatory markers were higher in patients without early recovery than in those with early recovery. Patients without early recovery showed unfavorable 1\u2010year outcome compared with patients with early recovery (\n P<\/jats:italic>\n =0.003). On multiple logistic regression, male sex, LV ejection fraction <45%, and acute neurologic disorders were associated with the absence of early recovery.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n TTS patients without early\n LV<\/jats:styled-content>\n recovery have different clinical characteristics and less favorable 1\u2010year outcome compared with patients with early recovery. The factors associated with the absence of early recovery included male sex, reduced LV ejection fraction, and acute neurologic events.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 01947621.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.011194","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T09:02:11Z","timestamp":1572598931000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry"],"prefix":"10.1161","volume":"8","author":[{"given":"Stjepan","family":"Jurisic","sequence":"first","affiliation":[{"name":"University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Gili","sequence":"additional","affiliation":[{"name":"University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland"},{"name":"Centro Cardiologico Monzino IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria L.","family":"Cammann","sequence":"additional","affiliation":[{"name":"University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kato","sequence":"additional","affiliation":[{"name":"University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland"},{"name":"Department of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad A.","family":"Szawan","sequence":"additional","affiliation":[{"name":"University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"D'Ascenzo","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medical Sciences AOU Citt\u00e0 della Salute e della Scienza University of Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milosz","family":"Jaguszewski","sequence":"additional","affiliation":[{"name":"First Department of Cardiology Medical University of Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bossone","sequence":"additional","affiliation":[{"name":"Heart Department University Hospital \u201cSan Giovanni di Dio e Ruggi d'Aragona\u201d Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Citro","sequence":"additional","affiliation":[{"name":"Heart Department University Hospital \u201cSan Giovanni di Dio e Ruggi d'Aragona\u201d Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annahita","family":"Sarcon","sequence":"additional","affiliation":[{"name":"University of Southern California, Keck School of Medicine Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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