{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T01:54:11Z","timestamp":1774576451017,"version":"3.50.1"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,4,16]]},"abstract":"\n Background<\/jats:title>\n Little is known about plasma apolipoprotein profiles in very preterm\u2010born and term\u2010born preschool children compared with the adult population. This is of particular interest because apolipoprotein composition might contribute to cardiometabolic outcome in later life.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Children aged 5 to 7\u00a0years born at term or with <32\u00a0weeks of gestation were included. Apolipoprotein concentrations were measured in plasma collected after an overnight fast using multiple\u2010reaction monitoring\u2010based mass spectrometry. Twelve apolipoproteins were measured in 26 former term and 38 former very preterm infants. Key findings were confirmed by assessing apolipoprotein levels using antibody\u2010based assays. Comparing children born term and preterm, apolipoprotein A\u2010I, A\u2010\n IV<\/jats:styled-content>\n , C\u2010\n II<\/jats:styled-content>\n , and C\u2010\n III<\/jats:styled-content>\n were significantly higher in the latter group. Term\u2010born children showed plasma levels of apolipoprotein C\u2010\n II<\/jats:styled-content>\n and C\u2010\n III<\/jats:styled-content>\n quantitatively similar to the adult range (Bruneck study). Hierarchical clustering analyses suggested that a higher proportion of apolipoprotein C\u2010\n III<\/jats:styled-content>\n and C\u2010\n II<\/jats:styled-content>\n reside on high\u2010density lipoprotein particles in children than in adults given the marked correlations of apolipoprotein C\u2010\n III<\/jats:styled-content>\n and C\u2010\n II<\/jats:styled-content>\n with high\u2010density lipoprotein cholesterol and apolipoprotein A\u2010I in children but not adults. High\u2010density lipoprotein cholesterol concentrations were similar in children and adults but the pattern of high\u2010density lipoprotein cholesterol\u2013associated apolipoproteins was different (lower apolipoprotein A\u2010I and C\u2010I but higher A\u2010\n II<\/jats:styled-content>\n , A\u2010\n IV<\/jats:styled-content>\n , and M).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our study defines apolipoprotein profiles in preschoolers and reports potential effects of prematurity. Further large\u2010scale studies are required to provide evidence whether this apolipoprotein signature of prematurity, including high apolipoprotein C\u2010\n II<\/jats:styled-content>\n and C\u2010\n III<\/jats:styled-content>\n levels, might translate into adverse cardiometabolic outcome in later life.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.011199","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T09:09:11Z","timestamp":1554887351000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Apolipoprotein Profiles in Very Preterm and Term\u2010Born Preschool Children"],"prefix":"10.1161","volume":"8","author":[{"given":"Anna","family":"Posod","sequence":"first","affiliation":[{"name":"Pediatrics II (Neonatology) Department of Pediatrics Medical University of Innsbruck 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