{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T11:34:04Z","timestamp":1771846444419,"version":"3.50.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,2,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cerebral amyloid angiopathy (\n              <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>\n              ) is a major cause of lobar intracerebral hemorrhage in elderly adults; however, presymptomatic diagnosis of\n              <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>\n              is difficult. Hereditary cerebral hemorrhage with amyloidosis\u2013Dutch type (\n              <jats:styled-content style=\"fixed-case\">HCHWA<\/jats:styled-content>\n              \u2010D) is a rare autosomal\u2010dominant disease that leads to pathology similar to sporadic\n              <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>\n              . Presymptomatic\n              <jats:styled-content style=\"fixed-case\">HCHWA<\/jats:styled-content>\n              \u2010D mutation carriers provide a unique opportunity to study\n              <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>\n              \u2010related changes before any symptoms have occurred. In this study we investigated early\n              <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>\n              \u2010related alterations in the white matter.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We investigated diffusion magnetic resonance imaging (\n              <jats:styled-content style=\"fixed-case\">dMRI<\/jats:styled-content>\n              ) data for 15 symptomatic and 11 presymptomatic\n              <jats:styled-content style=\"fixed-case\">HCHWA<\/jats:styled-content>\n              \u2010D mutation carriers and 30 noncarrier control participants using 4 different approaches. We looked at (1)\u00a0the relation between age and global\n              <jats:styled-content style=\"fixed-case\">dMRI<\/jats:styled-content>\n              measures for mutation carriers versus controls, (2) voxel\u2010wise d\n              <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n              , (3) independent component\u2010clustered\n              <jats:styled-content style=\"fixed-case\">dMRI<\/jats:styled-content>\n              measures, and (4) structural connectomics between presymptomatic or symptomatic carriers and controls. Fractional anisotropy decreased, and mean diffusivity and peak width of the skeletonized mean diffusivity increased significantly over age for mutation carriers compared with controls. In addition, voxel\u2010wise and independent component\u2010wise fractional anisotropy, and mean diffusivity, and structural connectomics were significantly different between\n              <jats:styled-content style=\"fixed-case\">HCHWA<\/jats:styled-content>\n              \u2010D patients and control participants, mainly in the periventricular frontal and occipital regions and in the occipital lobe. We found no significant differences between presymptomatic carriers and control participants.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The d\n              <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n              technique is sensitive in detecting alterations in symptomatic\n              <jats:styled-content style=\"fixed-case\">HCHWA<\/jats:styled-content>\n              \u2010d carriers but did not show alterations in presymptomatic carriers. This result indicates that d\n              <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n              may be less suitable for identifying early white matter changes in\n              <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.011288","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T10:00:41Z","timestamp":1549360841000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Multiple Approaches to Diffusion Magnetic Resonance Imaging in Hereditary Cerebral Amyloid Angiopathy Mutation Carriers"],"prefix":"10.1161","volume":"8","author":[{"given":"Tijn M.","family":"Schouten","sequence":"first","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden the Netherlands"},{"name":"Leiden Institute for Brain and Cognition Leiden University Leiden the Netherlands"},{"name":"Institute of Psychology Leiden University Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"de Vos","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden the Netherlands"},{"name":"Leiden Institute for Brain and Cognition Leiden University Leiden the Netherlands"},{"name":"Institute of Psychology Leiden University Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanneke","family":"van Rooden","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden the Netherlands"},{"name":"Leiden Institute for Brain and Cognition Leiden University Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J. 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J.","family":"Bouts","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden the Netherlands"},{"name":"Leiden Institute for Brain and Cognition Leiden University Leiden the Netherlands"},{"name":"Institute of Psychology Leiden University Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"van Opstal","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogier A.","family":"Feis","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden the Netherlands"},{"name":"Leiden Institute for Brain and Cognition Leiden University Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela M.","family":"Terwindt","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke J. H.","family":"Wermer","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"van Buchem","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"de Rooij","sequence":"additional","affiliation":[{"name":"Leiden Institute for Brain and Cognition Leiden University Leiden the Netherlands"},{"name":"Institute of Psychology Leiden University Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge A. R. 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