{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:28:51Z","timestamp":1793114931463,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"\n Background<\/jats:title>\n \n This study analyzed the effects on long\u2010term outcome of residual mitral regurgitation (\n MR<\/jats:styled-content>\n ) and mean mitral valve pressure gradient (\n MVPG<\/jats:styled-content>\n ) after percutaneous edge\u2010to\u2010edge mitral valve repair using the MitraClip system.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Two hundred fifty\u2010five patients who underwent percutaneous edge\u2010to\u2010edge mitral valve repair were analyzed. Kaplan\u2013Meier and Cox regression analyses were performed to evaluate the impact of residual\n MR<\/jats:styled-content>\n and\n MVPG<\/jats:styled-content>\n on clinical outcome. A combined clinical end point (all\u2010cause mortality,\n MV<\/jats:styled-content>\n surgery, redo procedure, implantation of a left ventricular assist device) was used. After percutaneous edge\u2010to\u2010edge mitral valve repair, mean\n MVPG<\/jats:styled-content>\n increased from 1.6\u00b11.0 to 3.1\u00b11.5\u00a0mm\u00a0Hg (\n P<\/jats:italic>\n <0.001). Reduction of\n MR<\/jats:styled-content>\n severity to \u22642+ postintervention was achieved in 98.4% of all patients. In the overall patient cohort, residual\n MR<\/jats:styled-content>\n was predictive of the combined end point while elevated\n MVPG<\/jats:styled-content>\n >4.4\u00a0mm\u00a0Hg was not according to Kaplan\u2013Meier and Cox regression analyses. We then analyzed the cohort with degenerative and that with functional\n MR<\/jats:styled-content>\n separately to account for these different entities. In the cohort with degenerative\n MR<\/jats:styled-content>\n , elevated\n MVPG<\/jats:styled-content>\n was associated with increased occurrence of the primary end point, whereas this was not observed in the cohort with functional\n MR<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n MVPG<\/jats:styled-content>\n >4.4\u00a0mm\u00a0Hg after MitraClip implantation was predictive of clinical outcome in the patient cohort with degenerative\n MR<\/jats:styled-content>\n . In the patient cohort with functional\n MR<\/jats:styled-content>\n ,\n MVPG<\/jats:styled-content>\n >4.4\u00a0mm\u00a0Hg was not associated with increased clinical events.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.011366","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T09:02:11Z","timestamp":1561712531000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["Elevated Mitral Valve Pressure Gradient Is Predictive of Long\u2010Term Outcome After Percutaneous Edge\u2010to\u2010Edge Mitral Valve Repair in Patients With Degenerative Mitral Regurgitation (MR), But Not in Functional MR"],"prefix":"10.1161","volume":"8","author":[{"given":"Johannes","family":"Patzelt","sequence":"first","affiliation":[{"name":"Departments of Cardiology and Cardiovascular Medicine University Hospital Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Affiliated Hospital of Qingdao University Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Sauter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine University Hospital Universit\u00e4tsklinikum Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Mezger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine University Hospital Universit\u00e4tsklinikum Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Nording","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine University Hospital Universit\u00e4tsklinikum Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Departments of Cardiology and Cardiovascular Medicine University Hospital Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Becker","sequence":"additional","affiliation":[{"name":"Departments of Cardiology and Cardiovascular Medicine University Hospital Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Patzelt","sequence":"additional","affiliation":[{"name":"ERBE Elektromedizin GmbH T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Heart Center University of Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Eitel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine University Hospital Universit\u00e4tsklinikum Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine University Hospital Universit\u00e4tsklinikum Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Bamberg","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schlensak","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery University Hospital Eberhard Karls University T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinrad","family":"Gawaz","sequence":"additional","affiliation":[{"name":"Departments of Cardiology and Cardiovascular Medicine University Hospital Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Boekstegers","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie und Angiologie Klinikum Siegburg Siegburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Schreieck","sequence":"additional","affiliation":[{"name":"Departments of Cardiology and Cardiovascular Medicine University Hospital Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Seizer","sequence":"additional","affiliation":[{"name":"Departments of Cardiology and Cardiovascular Medicine University Hospital Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald F.","family":"Langer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine University Hospital Universit\u00e4tsklinikum Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.018"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1166"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00558-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.169"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805374"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512913"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.004856"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001039"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.12.190"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.135061"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20917"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.09.007"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.11.082"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.01.006"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.12.280"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00134-7"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.09.038"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jeq031"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.06.066"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007485"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.117277"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv627"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.094"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"e_1_3_2_28_2","first-page":"H1718","article-title":"Physical and physiological determinants of transmitral velocity: numerical analysis","volume":"260","author":"Thomas JD","year":"1991","unstructured":"Thomas JD, Newell JB, Choong CY, Weyman AE. Physical and physiological determinants of transmitral velocity: numerical analysis. Am J Physiol. 1991;260:H1718\u2013H1731.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90556-8"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.910"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.000688"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.07.027"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.098"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.043"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.118.011366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:36:28Z","timestamp":1715600188000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.118.011366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,2]]},"references-count":33,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2019,7,2]]}},"alternative-id":["10.1161\/JAHA.118.011366"],"URL":"https:\/\/doi.org\/10.1161\/jaha.118.011366","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,2]]},"assertion":[{"value":"2018-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e011366"}}