{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:13:31Z","timestamp":1790208811425,"version":"4.1.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Homeless and vulnerably housed individuals are at increased risk for multimorbidity compared with the general population. We assessed prevalence of brain infarcts on neuroimaging and associations with vascular risk factors and cognitive performance in a prospective study of residents living in marginal housing.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Two hundred twenty\u2010eight participants underwent structured clinical interviews, targeted clinical, laboratory, and neuropsychological assessments, and magnetic resonance imaging with T\n              <jats:sub>1<\/jats:sub>\n              , T\n              <jats:sub>2<\/jats:sub>\n              \u2010fluid\u2010attenuated inversion recovery and susceptibility\u2010weighted images. Subjects underwent cognitive testing to assess premorbid\n              <jats:styled-content style=\"fixed-case\">IQ<\/jats:styled-content>\n              , verbal learning and memory, inhibition, sustained attention, mental flexibility, and decision making. In this sample (mean age 44.0\u00a0years [\n              <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n              9.4], 77% male), prevalence of conventional vascular risk factors was lower than in the general population apart from tobacco use (94%). Ten\u2010year Framingham risk for any cardiovascular event was 11.4%\u00b19.2%. Brain infarcts were present in 25\/228 (11%). All were ischemic (40% cortical, 56% lacunar, 4% both). Participants with infarcts were older than those without (48.9\u00b19.4 versus 43.4\u00b19.2,\n              <jats:italic>P<\/jats:italic>\n              =0.006). In a multivariable regression analysis, only age remained a significant predictor of brain infarcts (odds ratio 1.08, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.02\u20131.14,\n              <jats:italic>P<\/jats:italic>\n              =0.004). After controlling for age and education, the presence of infarct was a significant predictor of impaired decision making on the Iowa Gambling Task of decision making (\u03b2 \u221228.2, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              \u221242.7 to \u221214.1,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Prevalence of infarcts on neuroimaging in this disadvantaged, community\u2010dwelling cohort was much higher than expected for age and was associated with impaired decision making. Further research is needed to identify individuals at highest risk who may benefit from targeted preventative strategies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.011412","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T09:00:24Z","timestamp":1561626024000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence and Risk Factors of Brain Infarcts and Associations With Cognitive Performance in Tenants of Marginal Housing"],"prefix":"10.1161","volume":"8","author":[{"given":"Lily W.","family":"Zhou","sequence":"first","affiliation":[{"name":"Vancouver Stroke Program Division of Neurology Faculty of Medicine University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Panenka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of British Columbia Vancouver British Columbia Canada"},{"name":"British Columbia Provincial Neuropsychiatry Program Vancouver British Columbia Canada"},{"name":"British Columbia Mental Health and Substance Abuse Research Institute Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina M.","family":"Gicas","sequence":"additional","affiliation":[{"name":"Department of Psychology Simon Fraser University Burnaby British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen E.","family":"Thornton","sequence":"additional","affiliation":[{"name":"Department of Psychology Simon Fraser University Burnaby British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manraj K. 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