{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:34:27Z","timestamp":1780338867930,"version":"3.54.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,4,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Tissue inhibitor of metalloproteinases\u20101 (\n              <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\n              \u20101) and procollagen type\n              <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n              aminoterminal peptide are established circulating markers of extracellular matrix remodeling and associated with cardiovascular disease. The association of both biomarkers with incident congestive heart failure and chronic kidney disease (\n              <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n              ) in the community is not well studied.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We measured plasma total\n              <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\n              \u20101 and procollagen type\n              <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n              aminoterminal peptide levels in 922 Framingham participants (mean age, 57\u00a0years; 57% women) and related both biomarkers to the risk of incident\n              <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n              and congestive heart failure in multivariable\u2010adjusted Cox regression models. Plasma total\n              <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\n              \u20101 levels were positively associated with risk of incident\n              <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n              (164 events; hazard ratio per 1 SD in log\u2010biomarker, 1.90; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.53\u20132.37) in multivariable models, including adjustments for left ventricular mass, C\u2010reactive protein, and B\u2010type natriuretic peptide levels. The association of total\n              <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\n              \u20101 with risk of congestive heart failure was statistically significant in an age\u2010 and sex\u2010adjusted model, but was attenuated upon adjustment for conventional risk factors. Blood procollagen type\n              <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n              aminoterminal peptide levels were not related to the risk of\n              <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n              or congestive heart failure.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Higher baseline levels of total\n              <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\n              \u20101 conferred an increased risk for incident\n              <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n              , independent of conventional risk factors and circulating biomarkers of chronic systemic inflammation and neurohormonal activation. Our prospective observations in a large community\u2010based sample support the role of matrix remodeling in the pathogenesis of\n              <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.011426","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T09:00:59Z","timestamp":1553072459000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Association of Circulating Tissue Inhibitor of Metalloproteinases\u20101 and Procollagen Type III Aminoterminal Peptide Levels With Incident Heart Failure and Chronic Kidney Disease"],"prefix":"10.1161","volume":"8","author":[{"given":"Wolfgang","family":"Lieb","sequence":"first","affiliation":[{"name":"Framingham Heart Study Framingham MA"},{"name":"Institute of Epidemiology Kiel University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Xanthakis","sequence":"additional","affiliation":[{"name":"Framingham Heart Study Framingham MA"},{"name":"Section\u00a0of Preventive Medicine and Epidemiology Boston University School of Medicine Boston MA"},{"name":"Department of Biostatistics Boston University School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandran S.","family":"Vasan","sequence":"additional","affiliation":[{"name":"Framingham Heart Study Framingham MA"},{"name":"Section\u00a0of Preventive Medicine and Epidemiology Boston University School of Medicine Boston MA"},{"name":"Department of Epidemiology Boston University School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80312-X"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31821823d9"},{"key":"e_1_3_1_4_2","first-page":"60","article-title":"Chronic kidney disease and fibrosis: the role of uremic retention solutes","volume":"2","author":"Mutsaers HA","year":"2015","unstructured":"Mutsaers HA, Stribos EG, Glorieux G, Vanholder R, Olinga P. 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