{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:08:39Z","timestamp":1793311719401,"version":"4.5.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,5,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Several devices have been proposed to assess arterial stiffness in clinical daily use over the past few years, by estimating aortic pulse wave velocity (PWV) from a single measurement of brachial oscillometric blood pressure, using patented algorithms. It is uncertain if these systems are able to provide additional elements, beyond the contribution carried by age and blood pressure levels, in the definition of early vascular damage expressed by the stiffening of the arterial wall.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The aim of our study was to compare the estimated algorithm\u2010based PWV values, provided by the Mobil\u2010O\u2010Graph system, with the standard noninvasive assessment of aortic PWV in patients with Marfan syndrome (ie, in subjects characterized by premature aortic stiffening and low blood pressure values). Aortic stiffness was simultaneously evaluated by carotid\u2010femoral PWV with a validated arterial tonometer and estimated with an arm cuff\u2013based ambulatory blood pressure monitoring Mobil\u2010O\u2010Graph device on 103 patients with Marfan syndrome (50 men; mean\u00b1\n              <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n              age, 38\u00b115\u00a0years). Aortic PWV, estimated by the Mobil\u2010O\u2010Graph, was significantly (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) lower (mean\u00b1\n              <jats:styled-content style=\"fixed-case\">SD,<\/jats:styled-content>\n              6.1\u00b11.3\u00a0m\/s) than carotid\u2010femoral PWV provided by arterial tonometry (mean\u00b1\n              <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n              , 8.8\u00b13.1\u00a0m\/s). The average of differences between\n              <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>\n              values provided by the 2 methods (\u00b11.96\u00d7SD) was \u22122.7\u00b15.7\u00a0m\/s.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The Mobil\u2010O\u2010Graph provides PWV values related to an ideal subject for a given age and blood pressure, but it is not able to evaluate early vascular aging expressed by high PWV in the individual patient. This is well shown in patients with Marfan syndrome.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.011440","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T09:14:42Z","timestamp":1556183682000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Unreliable Estimation of Aortic Pulse Wave Velocity Provided by the Mobil\u2010O\u2010Graph Algorithm\u2010Based System in Marfan Syndrome"],"prefix":"10.1161","volume":"8","author":[{"given":"Paolo","family":"Salvi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular, Neural and Metabolic Sciences Istituto Auxologico Italiano IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Furlanis","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical and Health Sciences University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Grillo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Neural and Metabolic Sciences Istituto Auxologico Italiano IRCCS Milan Italy"},{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Pini","sequence":"additional","affiliation":[{"name":"Department of Cardiology Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco Rare Disease Center \u201cMarfan Clinic\u201d Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Salvi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics Fondazione IRCCS Policlinico San Matteo University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Marelli","sequence":"additional","affiliation":[{"name":"Department of Cardiology Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco Rare Disease Center \u201cMarfan Clinic\u201d Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Rovina","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical and Health Sciences University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Moretti","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Fondazione IRCCS Policlinico San Matteo University of Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Gaetano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Pintassilgo","sequence":"additional","affiliation":[{"name":"Hospital Garcia de Orta, Medicina Interna Almada Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Faini","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Neural and Metabolic Sciences Istituto Auxologico Italiano IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Fabris","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical and Health Sciences University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Carretta","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical and Health Sciences University of Trieste Trieste Italy"},{"name":"Institute of Biomedicine and Molecular Immunology \u201cA. 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