{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:54:59Z","timestamp":1787018099236,"version":"build-2736575974"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,2,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      People living with\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">PLWH<\/jats:styled-content>\n                      ) are at increased risk of cardiovascular disease, including hypertension, which persists despite effective plasma viral suppression on antiretroviral therapy.\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      infection is characterized by long\u2010term alterations in immune function, but the contribution of immune factors to hypertension in\n                      <jats:styled-content style=\"fixed-case\">PLWH<\/jats:styled-content>\n                      is not fully understood. Prior studies have found that both innate and adaptive immune cell activation contributes to hypertension.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We hypothesized that chronic inflammation may contribute to hypertension in\n                      <jats:styled-content style=\"fixed-case\">PLWH<\/jats:styled-content>\n                      . To test this hypothesis, we enrolled a cohort of 70\n                      <jats:styled-content style=\"fixed-case\">PLWH<\/jats:styled-content>\n                      (44% hypertensive) on a long\u2010term single antiretroviral therapy regimen for broad phenotyping of inflammation biomarkers. We found that hypertensive\n                      <jats:styled-content style=\"fixed-case\">PLWH<\/jats:styled-content>\n                      had higher levels of inflammatory cytokines, including tumor necrosis factor\u2010\u03b1 receptor 1, interleukin\u20106, interleukin\u201017, interleukin\u20105, intercellular adhesion molecule 1 and macrophage inflammatory protein\u20101\u03b1. After adjustment for age, sex, and fat mass index, the circulating eosinophils remained significantly associated with hypertension. On the basis of these results, we assessed the relationship of eosinophils and hypertension in 2 cohorts of 50 and 81 039 similar\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      \u2010negative people; although eosinophil count was associated with prevalent hypertension, this relationship was abrogated by body mass index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      These findings may represent a unique linkage between immune status and cardiovascular physiological characteristics in\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      infection, which should be evaluated further.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.118.011450","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T05:23:12Z","timestamp":1581916992000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Elevated Eosinophils as a Feature of Inflammation Associated With Hypertension in Virally Suppressed People Living With HIV"],"prefix":"10.1161","volume":"9","author":[{"given":"Sepiso K.","family":"Masenga","sequence":"first","affiliation":[{"name":"School of Medicine and Health Sciences Mulungushi University Livingstone Zambia"},{"name":"Department of Biomedical Sciences School of Health Sciences University of Zambia Lusaka Zambia"},{"name":"Vanderbilt Institute for Global Health Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Elijovich","sequence":"additional","affiliation":[{"name":"Division of Clinical 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