{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:25:35Z","timestamp":1760955935864,"version":"3.41.2"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,5,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Concerns exist about reliability of pressure\u2010wire\u2010guided coronary revascularization of non\u2010infarct\u2010related arteries (non\u2010\n              <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content>\n              ). We investigated whether physiological assessment of non\u2010\n              <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content>\n              during the subacute phase of myocardial infarction might be flawed by microcirculatory dysfunction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We analyzed non\u2010\n              <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content>\n              that underwent fractional flow reserve, coronary flow reserve, and the index of microcirculatory resistance assessment. Microcirculation and hyperemic response were evaluated in 49 acute myocardial infarction patients (59 non\u2010\n              <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content>\n              ) and compared with a matched control group of 46 stable angina (\n              <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n              ) patients (59 vessels). Time between acute myocardial infarction to physiological interrogation was 5.9\u00b12.4\u00a0days. Fractional flow reserve was similar in both groups (0.79\u00b10.11 in non\u2010\n              <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content>\n              versus 0.80\u00b10.13 in\n              <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n              vessels,\n              <jats:italic>P<\/jats:italic>\n              =0.527). Lower coronary flow reserve values were found in non\u2010\n              <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content>\n              compared with\n              <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n              vessels (1.77 [1.25\u20132.76] versus 2.44 [1.63\u20134.00],\n              <jats:italic>P<\/jats:italic>\n              =0.018), primarily driven by an increased baseline flow in non\u2010\n              <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content>\n              (rest mean transit time 0.58 [0.32\u20130.83] versus 0.65\u00a0s [0.39\u20131.20],\n              <jats:italic>P<\/jats:italic>\n              =0.045), whereas the hyperemic flow was similar (hyperemic mean transit time 0.26 [0.20\u20130.42] versus 0.26\u00a0s [0.18\u20130.35],\n              <jats:italic>P<\/jats:italic>\n              =0.873). No differences were found regarding index of microcirculatory resistance (15.6 [10.4\u201321.8] in non\u2010\n              <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content>\n              versus 16.7 [11.6\u201323.6] U in\n              <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n              vessels,\n              <jats:italic>P<\/jats:italic>\n              =0.559). During adenosine infusion, the hyperemic response was similar in both groups (non\u2010\n              <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content>\n              versus\n              <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n              vessels) in terms of the resistive reserve ratio (3.1\u00b12.1 versus 3.7\u00b12.2,\n              <jats:italic>P<\/jats:italic>\n              =0.118).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In the subacute phase of myocardial infarction, non\u2010\n              <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content>\n              show an increased baseline flow that may cause abnormal coronary flow reserve despite preserved hyperemic flow. In non\u2010\n              <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content>\n              , microcirculatory resistance and adenosine\u2010induced hyperemic response are similar to those found in\n              <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n              patients. From a physiological perspective, these findings support the use of fractional flow reserve to interrogate non\u2010\n              <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content>\n              during the subacute phase of myocardial infarction.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.011534","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T09:21:10Z","timestamp":1556097670000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Coronary Microcirculation Downstream Non\u2010Infarct\u2010Related Arteries in the Subacute Phase of Myocardial Infarction: Implications for Physiology\u2010Guided Revascularization"],"prefix":"10.1161","volume":"8","author":[{"given":"Hern\u00e1n","family":"Mej\u00eda\u2010Renter\u00eda","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC and Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Myung","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Heart Vascular Stroke Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina W.","family":"van der Hoeven","sequence":"additional","affiliation":[{"name":"Department of Cardiology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nieves","family":"Gonzalo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC and Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Jim\u00e9nez\u2010Quevedo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC and Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Nombela\u2010Franco","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC and Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n J.","family":"N\u00fa\u00f1ez\u2010Gil","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC and Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Salinas","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC and Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Del Trigo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC and Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Cerrato","sequence":"additional","affiliation":[{"name":"Interventional Cardiology San Luigi Gonzaga University Hospital Orbassano and Rivoli Infermi Hospital Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"van Royen","sequence":"additional","affiliation":[{"name":"Department of Cardiology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Knaapen","sequence":"additional","affiliation":[{"name":"Department of Cardiology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bon\u2010Kwon","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiovascular Center Seoul National University Hospital Seoul Korea"},{"name":"Institute on Aging Seoul National University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Macaya","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC and Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Fern\u00e1ndez\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC and Universidad Complutense de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Escaned","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC and Universidad Complutense de Madrid Madrid 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