{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:36:22Z","timestamp":1792596982659,"version":"4.5.0"},"reference-count":62,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,4,2]]},"abstract":"\n Background<\/jats:title>\n Optimally treated patients with coarctation of the aorta remain at risk for late vascular dysfunction. The effect of treatment modality on vascular function is unknown. The LOVE\u2010COARCT (Long\u2010term Outcomes and Vascular Evaluation After Successful Coarctation of the Aorta Treatment) study was done to compare vascular function in patients with coarctation of the aorta treated with surgery, balloon dilation (BD), or stent implantation.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In treated coarctation of the aorta patients without residual coarctation, we prospectively compared aortic stiffness by applanation tonometry and cardiac magnetic resonance; endothelial function by endothelial pulse amplitude testing; blood pressure (\n BP<\/jats:styled-content>\n ) phenotype by office\n BP<\/jats:styled-content>\n , ambulatory\n BP<\/jats:styled-content>\n monitoring, and\n BP<\/jats:styled-content>\n response to exercise; left ventricular mass by cardiac magnetic resonance; and blood biomarkers of endothelial function, inflammation, vascular wall function, and extracellular matrix. Participants included 75 patients treated with surgery (n=28),\n BD<\/jats:styled-content>\n (n=23), or stent (n=24). Groups had similar age at enrollment, coarctation of the aorta severity, residual gradient, and metabolic profile, but differed by age at treatment. Prevalence of systemic hypertension, aortic stiffness, endothelial function, and left ventricular mass were similar among treatment groups. However,\n BD<\/jats:styled-content>\n patients had more\u2010distensible ascending aortas, lower peak systolic\n BP<\/jats:styled-content>\n during exercise, less impairment in diurnal\n BP<\/jats:styled-content>\n variation, and lower inflammatory biomarkers. Results were unchanged after adjustment for potential confounders, including age at treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In our cohort of patients without residual coarctation, treatment modality was not associated with major vascular outcomes, even though there were some favorable vascular characteristics in the\n BD<\/jats:styled-content>\n patients. Although this suggests that choice of treatment modality should continue to be driven by likelihood of achieving a good anatomical result, more long\u2010term studies are required to assess the clinical significance of the more\u2010optimal results of secondary markers of vascular function in\n BD<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 03262753.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.011536","type":"journal-article","created":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T05:00:26Z","timestamp":1553922026000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Impact of Treatment Modality on Vascular Function in Coarctation of the Aorta: The LOVE\u2010COARCT Study"],"prefix":"10.1161","volume":"8","author":[{"given":"Jos\u00e9 D.","family":"Martins","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology Hospital de Santa Marta Centro Hospitalar de Lisboa Central Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Zachariah","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Texas Children's Hospital and Baylor College of Medicine Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif Seda","family":"Selamet Tierney","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Lucile Packard Children's Hospital and Stanford University Palo Alto CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uyen","family":"Truong","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital Colorado Denver CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaine A.","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Texas Children's Hospital and Baylor College of Medicine Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby","family":"Kutty","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital and Medical Center Omaha NE"},{"name":"University of Nebraska College of Medicine Omaha NE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah D.","family":"de Ferranti","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Guarino","sequence":"additional","affiliation":[{"name":"CEDOC Chronic Diseases Nova Medical School Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boban","family":"Thomas","sequence":"additional","affiliation":[{"name":"Resson\u00e2ncia Magn\u00e9tica Caselas S.A. Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department Instituto Superior T\u00e9cnico Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio","family":"Marinho","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Department Hospital Pedi\u00e1trico de Coimbra Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ant\u00f3nio","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Hospital de Santa Marta Centro Hospitalar de Lisboa Central Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberlee","family":"Gauvreau","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Jalles","sequence":"additional","affiliation":[{"name":"Resson\u00e2ncia Magn\u00e9tica Caselas S.A. Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Geva","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel M.","family":"Carmo","sequence":"additional","affiliation":[{"name":"CEDOC Chronic Diseases Nova Medical School Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the LOVE\u2010COARCT Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.053"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi037"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.158287"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.09.008"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4373-8"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.07.052"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-307035"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.06.016"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.003071"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc37t1.094900"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.529792"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.195065"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.01.037"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.01.030"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.0600031083.x"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.01.168"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.02.071"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.112231"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.66.3.513"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(83)90080-2"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.66.6.1280"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.04.098"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-008-9381-2"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.4103\/apc.APC_64_18"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90198-V"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq165"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.08.062"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.12.028"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.S2.555"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000107251.49515.c2"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000007"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000154900.76284.F6"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb17319.x"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000126823.07732.D5"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2006.04.003"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107477"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000048894.99865.02"},{"key":"e_1_3_1_40_2","first-page":"122","volume-title":"Advances in the Management and Surveillance of Patients With Aortic Coarctation","author":"Walhout RJ","year":"2009","unstructured":"Walhout RJ. Assessment of proximal and distal aortic properties with magnetic resonance after successful coarctation management in adults. In: Wlahout RJ, ed. Advances in the Management and Surveillance of Patients With Aortic Coarctation. 2009\/06\/26 ed. Amsterdam: Universiteit Amsterdam; 2009:122\u2013130."},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm528"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-77"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.057"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80418-4"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-305739"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0522-2"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.090"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.04.027"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.88.2.163"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.001978"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(98)00234-9"},{"key":"e_1_3_1_52_2","first-page":"II27","article-title":"Systolic hypertension during submaximal exercise after correction of coarctation of aorta","volume":"50","author":"James FW","year":"1974","unstructured":"James FW, Kaplan S. Systolic hypertension during submaximal exercise after correction of coarctation of aorta. Circulation. 1974;50:II27\u2013II34.","journal-title":"Circulation"},{"key":"e_1_3_1_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.09.037"},{"key":"e_1_3_1_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.14.1831"},{"key":"e_1_3_1_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hps053"},{"key":"e_1_3_1_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10262"},{"key":"e_1_3_1_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.016"},{"key":"e_1_3_1_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.12.091"},{"key":"e_1_3_1_59_2","doi-asserted-by":"publisher","DOI":"10.1080\/10623320600972143"},{"key":"e_1_3_1_60_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.841981"},{"key":"e_1_3_1_61_2","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2009.208835"},{"key":"e_1_3_1_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12406"},{"key":"e_1_3_1_63_2","doi-asserted-by":"publisher","DOI":"10.1177\/152660280701400421"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.118.011536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:44:09Z","timestamp":1715586249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.118.011536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,2]]},"references-count":62,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,4,2]]}},"alternative-id":["10.1161\/JAHA.118.011536"],"URL":"https:\/\/doi.org\/10.1161\/jaha.118.011536","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,2]]},"assertion":[{"value":"2018-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e011536"}}