{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:07:06Z","timestamp":1783544826944,"version":"3.55.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,8,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Despite limitations as a stand\u2010alone parameter, left ventricular (LV) ejection fraction is the preferred measure of myocardial function and marker for postinfarction risk stratification.\n              <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n              myocardial uniformity alterations may provide superior prognostic information after acute myocardial infarction, which was the subject of this study.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Consecutive patients with acute myocardial infarction (n=1082; median age: 63\u00a0years; 75% male) undergoing cardiac magnetic resonance at a median of 3\u00a0days after infarction were included in this multicenter observational study. Circumferential and radial uniformity ratio estimates were derived from cardiac magnetic resonance feature tracking as markers of mechanical uniformity alterations (values between 0 and 1 with 1 reflecting perfect uniformity). The clinical end point was the 12\u2010month rate of major adverse cardiac events, consisting of all\u2010cause death, reinfarction, and new congestive heart failure. Patients with major adverse cardiac events (n=73) had significantly impaired circumferential uniformity ratio estimates (0.76 [interquartile range: 0.67\u20130.86] versus 0.84 [interquartile range: 0.76\u20130.89];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and radial uniformity ratio estimates (0.69 [interquartile range: 0.60\u20130.79] versus 0.76 [interquartile range: 0.67\u20130.83];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) compared with patients without events. Although uniformity estimates did not provide independent prognostic information in the overall cohort, a circumferential uniformity ratio estimate below the median of 0.84 emerged as an independent predictor of outcome in postinfarction patients with LV ejection fraction &gt;35% (n=959), even after adjustment for established risk factors (hazard ratio: 1.99; 95% CI, 1.06\u20133.74;\n              <jats:italic>P<\/jats:italic>\n              =0.033 in multivariable Cox regression analysis). In contrast, LV ejection fraction was not associated with adverse events in this subgroup of patients with acute myocardial infarction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Cardiac magnetic resonance\u2013derived estimates of mechanical uniformity alterations are novel markers for risk assessment after acute myocardial infarction, and the circumferential uniformity ratio estimate provides independent prognostic information for patients with preserved or only moderately reduced LV ejection fraction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.011576","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T09:04:06Z","timestamp":1565168646000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Cardiac Magnetic Resonance Left Ventricular Mechanical Uniformity Alterations for Risk Assessment After Acute Myocardial Infarction"],"prefix":"10.1161","volume":"8","author":[{"given":"Thomas","family":"Stiermaier","sequence":"first","affiliation":[{"name":"Medical Clinic II (Cardiology\/Angiology\/Intensive Care Medicine) University Heart Center L\u00fcbeck University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren J.","family":"Backhaus","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University Medical Center G\u00f6ttingen Georg\u2010August University G\u00f6ttingen Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site G\u00f6ttingen G\u00f6ttingen 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G\u00f6ttingen Georg\u2010August University G\u00f6ttingen Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Boom","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University Medical Center G\u00f6ttingen Georg\u2010August University G\u00f6ttingen Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Lamata","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering School of Biomedical Engineering and Imaging Sciences King's College of London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes T.","family":"Kowallick","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site G\u00f6ttingen G\u00f6ttingen Germany"},{"name":"Institute for Diagnostic and Interventional Radiology University Medical Center G\u00f6ttingen Georg\u2010August University G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Lotz","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site G\u00f6ttingen G\u00f6ttingen Germany"},{"name":"Institute for Diagnostic and Interventional Radiology University Medical Center G\u00f6ttingen Georg\u2010August University G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Gutberlet","sequence":"additional","affiliation":[{"name":"Department of Radiology Heart Center Leipzig at University of Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"de Waha\u2010Thiele","sequence":"additional","affiliation":[{"name":"Medical Clinic II (Cardiology\/Angiology\/Intensive Care Medicine) University Heart Center L\u00fcbeck University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Desch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology Heart Center Leipzig at University of Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Hasenfu\u00df","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University Medical Center G\u00f6ttingen Georg\u2010August University G\u00f6ttingen Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site G\u00f6ttingen G\u00f6ttingen 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