{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:37:07Z","timestamp":1783024627269,"version":"3.54.6"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,5,7]]},"abstract":"\n Background<\/jats:title>\n \n It is uncertain whether there is an association between left ventricular (LV) ejection fraction (\n LVEF<\/jats:styled-content>\n ) or\n LV<\/jats:styled-content>\n wall motion abnormality and embolic stroke of undetermined source (\n ESUS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We performed a retrospective, cross\u2010sectional study of patients with acute ischemic stroke enrolled in the CAESAR (Cornell Acute Stroke Academic Registry) from 2011 to 2016. We restricted this study to patients with\n ESUS<\/jats:styled-content>\n and, as controls, those with small\u2010 and large\u2010artery ischemic strokes.\n LVEF<\/jats:styled-content>\n had to be above 35% to be considered\n ESUS<\/jats:styled-content>\n . In a secondary analysis, we excluded patients with\n ESUS<\/jats:styled-content>\n who had any evidence of ipsilateral carotid atherosclerosis. Multiple logistic regression was used to evaluate whether\n LVEF<\/jats:styled-content>\n or\n LV<\/jats:styled-content>\n wall motion abnormality was associated with\n ESUS<\/jats:styled-content>\n . We performed a confirmatory study at another tertiary\u2010care center. We identified 885 patients with\n ESUS<\/jats:styled-content>\n (n=503) or small\u2010 or large\u2010artery strokes (n=382). Among the entire cohort,\n LVEF<\/jats:styled-content>\n was not associated with\n ESUS<\/jats:styled-content>\n (odds ratio per 5% decrement in\n LVEF<\/jats:styled-content>\n , 1.0; 95% CI, 1.0\u20131.1) and\n LV<\/jats:styled-content>\n wall motion abnormality was not associated with\n ESUS<\/jats:styled-content>\n (odds ratio, 0.9; 95% CI, 0.5\u20131.6). The results were identical in our confirmatory study. In our secondary analysis excluding\n ESUS<\/jats:styled-content>\n patients with any evidence of ipsilateral carotid atherosclerosis, there was an association between\n LVEF<\/jats:styled-content>\n and\n ESUS<\/jats:styled-content>\n (odds ratio per 5% decrement in\n LVEF<\/jats:styled-content>\n , 1.2; 95% CI, 1.0\u20131.5;\n P<\/jats:italic>\n =0.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Among the entire cohort, no association existed between\n LVEF<\/jats:styled-content>\n or\n LV<\/jats:styled-content>\n wall motion abnormality and\n ESUS<\/jats:styled-content>\n ; however, after excluding\n ESUS<\/jats:styled-content>\n patients with any evidence of ipsilateral carotid atherosclerosis, lower\n LVEF<\/jats:styled-content>\n appeared to be associated with\n ESUS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.011593","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T14:57:16Z","timestamp":1557154636000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Association Between Left Ventricular Ejection Fraction, Wall Motion Abnormality, and Embolic Stroke of Undetermined Source"],"prefix":"10.1161","volume":"8","author":[{"given":"Shobana","family":"Ramasamy","sequence":"first","affiliation":[{"name":"Clinical and Translational Neuroscience Unit Feil Family Brain and Mind Research Institute Weill Cornell Medical College New York NY"},{"name":"Department of Neurology Weill Cornell Medical College New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi","family":"Yaghi","sequence":"additional","affiliation":[{"name":"Department of Neurology Warren Alpert Medical School of Brown University Providence RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setareh","family":"Salehi Omran","sequence":"additional","affiliation":[{"name":"Clinical and Translational Neuroscience Unit Feil Family Brain and Mind Research Institute Weill Cornell Medical College New York NY"},{"name":"Department of Neurology Weill Cornell Medical College New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Lerario","sequence":"additional","affiliation":[{"name":"Clinical and Translational Neuroscience Unit Feil Family Brain and Mind Research Institute Weill Cornell Medical College New York NY"},{"name":"Department of Neurology Weill Cornell Medical College New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Devereux","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medical College New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Okin","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medical College New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medical College New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak B.","family":"Navi","sequence":"additional","affiliation":[{"name":"Clinical and Translational Neuroscience Unit Feil Family Brain and Mind Research Institute Weill Cornell Medical College New York NY"},{"name":"Department of Neurology Weill Cornell Medical College New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hooman","family":"Kamel","sequence":"additional","affiliation":[{"name":"Clinical and Translational Neuroscience Unit Feil Family Brain and Mind Research Institute Weill Cornell Medical College New York NY"},{"name":"Department of Neurology Weill Cornell Medical College New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander E.","family":"Merkler","sequence":"additional","affiliation":[{"name":"Clinical and Translational Neuroscience Unit Feil Family Brain and Mind Research Institute Weill Cornell Medical College New York NY"},{"name":"Department of Neurology Weill Cornell Medical College New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250410"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00132-5"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70310-7"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.652149"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00324-7"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20617"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.09.001"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00019-3"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000227121.34717.40"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018263"},{"key":"e_1_3_1_13_2","first-page":"VI94","article-title":"Incidence 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The V\u2010HeFT VA Cooperative Studies Group","volume":"87","author":"Dunkman WB","year":"1993","unstructured":"Dunkman WB, Johnson GR, Carson PE, Bhat G, Farrell L, Cohn JN. Incidence of thromboembolic events in congestive heart failure. The V\u2010HeFT VA Cooperative Studies Group. Circulation. 1993;87:VI94\u2013VI101.","journal-title":"Circulation"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1802686"},{"key":"e_1_3_1_15_2","doi-asserted-by":"crossref","unstructured":"Diener HC Sacco RL Easton JD Granger CB Cronin L Duffy C Cotton D Bruekmann M Sacco RL. RE\u2010SPECT ESUS: dabigatran versus acetylsalicylic acid for stroke prevention in patients with embolic stroke of undetermined source. Abstract 100 presented at the World Stroke Congress October 17\u201320 2018 Montreal Quebec Canada.","DOI":"10.26226\/morressier.5aeac941521e300021138028"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003588"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.1.61"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8175.2000.00547.x"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8175.2002.00383.x"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.118.011593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:36:49Z","timestamp":1715600209000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.118.011593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,7]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,5,7]]}},"alternative-id":["10.1161\/JAHA.118.011593"],"URL":"https:\/\/doi.org\/10.1161\/jaha.118.011593","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,7]]},"assertion":[{"value":"2018-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e011593"}}