{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:59:54Z","timestamp":1778803194078,"version":"3.51.4"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,4,2]]},"abstract":"\n Background<\/jats:title>\n \n Patients with chronic total occlusion (\n CTO<\/jats:styled-content>\n ) may not participate in regular exercise because of refractory angina. Exercise participation after percutaneous coronary intervention (PCI) for\n CTO<\/jats:styled-content>\n (\n CTO PCI<\/jats:styled-content>\n ) and the association of exercise with health status after\n CTO PCI<\/jats:styled-content>\n is unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Overall, 1000 patients enrolled in the Outcomes, Patient Health Status, and Efficiency in Chronic Total Occlusion OPEN CTO is a registry were asked about participation in regular exercise at baseline and 12\u00a0months after\n CTO PCI<\/jats:styled-content>\n , and the frequency of exercise (<1, 1\u20132, \u22653 times\/week) was collected among exercisers. Health status was assessed using the Seattle Angina Questionnaire (\n SAQ<\/jats:styled-content>\n ). Multivariable regression assessed 12\u2010month health status change across 4 groups defined by exercise frequency at baseline and 12\u00a0months after\n CTO PCI<\/jats:styled-content>\n (no regular exercise at baseline and 12\u00a0months, reduced, increased, and consistent exercise at 12 months). Among 869 patients with complete exercise data, the proportion that exercised regularly increased from 33.5% at baseline to 56.6% 12\u00a0months after\n CTO PCI<\/jats:styled-content>\n (\n P<\/jats:italic>\n <0.01). Predictors of regular exercise at 12\u00a0months included baseline exercise, smoking, baseline and increase in\n SAQ<\/jats:styled-content>\n scores for angina frequency, physical limitation, quality of life, and summary. After multivariable adjustment, consistent or increased exercise frequency was associated with significantly greater improvement in\n SAQ<\/jats:styled-content>\n scores for angina frequency, physical limitation, quality of life, and summary (\n P<\/jats:italic>\n <0.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Participation in regular exercise increased significantly 12\u00a0months after\n CTO PCI<\/jats:styled-content>\n , and patients who had greater health status benefit after\n PCI<\/jats:styled-content>\n were more likely to exercise regularly at 12\u00a0months.\n CTO PCI<\/jats:styled-content>\n may enable coronary artery disease patients with limiting symptoms to engage in regular exercise and to support better long\u2010term outcomes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.011629","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T09:01:48Z","timestamp":1553850108000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Physical Activity After Percutaneous Coronary Intervention for Chronic Total Occlusion and Its Association With Health Status"],"prefix":"10.1161","volume":"8","author":[{"given":"Poghni A.","family":"Peri\u2010Okonny","sequence":"first","affiliation":[{"name":"Saint Luke's Mid America Heart Institute Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Spertus","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute Kansas City MO"},{"name":"University of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Aaron","family":"Grantham","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute Kansas City MO"},{"name":"University of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensey","family":"Gosch","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Kirtane","sequence":"additional","affiliation":[{"name":"Columbia University New York City NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Sapontis","sequence":"additional","affiliation":[{"name":"Monash Heart Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Lombardi","sequence":"additional","affiliation":[{"name":"University of Washington Seattle WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitri","family":"Karmpaliotis","sequence":"additional","affiliation":[{"name":"Columbia University New York City NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Moses","sequence":"additional","affiliation":[{"name":"Columbia University New York City NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Wellspan York Hospital York PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam C.","family":"Salisbury","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute Kansas City MO"},{"name":"University of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v8.i10.575"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25303"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.08.017"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25264"},{"key":"e_1_3_1_6_2","first-page":"83","article-title":"Percutaneous coronary intervention of coronary chronic total occlusions improves peak oxygen uptake during cardiopulmonary exercise testing","volume":"29","author":"Abdullah SM","year":"2017","unstructured":"Abdullah SM, Hastings JL, Amsavelu S, Garcia\u2010Morales F, Hendrix F, Karatasakis A, Danek BA, Karacsonyi J, Rangan BV, Roesle M, Khalili H, Banerjee S, Brilakis ES. 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