{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:25:10Z","timestamp":1791419110447,"version":"4.3.3"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,5,21]]},"abstract":"\n Background<\/jats:title>\n \n Cardiac magnetic resonance (\n CMR)<\/jats:styled-content>\n differentiates neoplasm from thrombus via contrast enhancement; positron emission tomography (\n PET)<\/jats:styled-content>\n assesses metabolism. The relationship between\n CMR<\/jats:styled-content>\n contrast enhancement and metabolism on\n PET<\/jats:styled-content>\n is unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n The population included 121 cancer patients undergoing\n CMR<\/jats:styled-content>\n and\n 18<\/jats:sup>\n F\u2010fluorodeoxyglucose (\n 18<\/jats:sup>\n F\u2010\n FDG)<\/jats:styled-content>\n \u2013\n PET<\/jats:styled-content>\n , including 66 with cardiac masses and cancer\u2010matched controls. Cardiac mass etiology (neoplasm, thrombus) on\n CMR<\/jats:styled-content>\n was defined by late gadolinium enhancement;\n PET<\/jats:styled-content>\n was read blinded to\n CMR<\/jats:styled-content>\n for diagnostic performance, then colocalized to measure\n FDG<\/jats:styled-content>\n avidity. Of\n CMR<\/jats:styled-content>\n \u2010evidenced thrombi (all nonenhancing), none were detected by\n PET<\/jats:styled-content>\n . For neoplasm,\n PET<\/jats:styled-content>\n yielded reasonable sensitivity (70\u201383%) and specificity (75\u201388%). Lesions undetected by\n PET<\/jats:styled-content>\n were more likely to be highly mobile (\n P<\/jats:italic>\n =0.001) despite similar size (\n P<\/jats:italic>\n =0.33). Among nonmobile neoplasms,\n PET<\/jats:styled-content>\n sensitivity varied in relation to extent of\n CMR<\/jats:styled-content>\n \u2010evidenced avascularity; detection of diffusely enhancing or mixed lesions was higher versus predominantly avascular neoplasms (87% versus 63%). Colocalized analyses demonstrated 2\u2010 to 4\u2010fold higher\n FDG<\/jats:styled-content>\n uptake in neoplasm versus thrombus (\n P<\/jats:italic>\n <0.001);\n FDG<\/jats:styled-content>\n uptake decreased stepwise when neoplasms were partitioned based on extent of avascularity on late gadolinium enhancement CMR (\n P<\/jats:italic>\n \u22640.001). Among patients with neoplasm, signal\u2010to\u2010noise ratio on late gadolinium enhancement CMR moderately correlated with standardized uptake values on\n PET<\/jats:styled-content>\n (\n r<\/jats:italic>\n =0.42\u20130.49,\n P<\/jats:italic>\n <0.05). Mortality was higher among patients with\n CMR<\/jats:styled-content>\n \u2010evidenced neoplasm versus controls (hazard ratio: 1.99 [95%\n CI,<\/jats:styled-content>\n 1.1\u20133.6];\n P<\/jats:italic>\n =0.03) despite nonsignificant differences when partitioned via\n FDG<\/jats:styled-content>\n avidity (hazard ratio: 1.56 [95%\n CI,<\/jats:styled-content>\n 0.85\u20132.74];\n P<\/jats:italic>\n =0.16). Among FDG\u2010positive neoplasms detected concordantly with\n CMR<\/jats:styled-content>\n , mortality risk versus cancer\u2010matched controls was equivalently increased (hazard ratio: 2.12 [95%\n CI,<\/jats:styled-content>\n 1.01\u20134.44];\n P<\/jats:italic>\n =0.047).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n CMR<\/jats:styled-content>\n contrast enhancement provides a criterion for neoplasm that parallels\n FDG<\/jats:styled-content>\n \u2010evidenced metabolic activity and stratifies prognosis. Extent of tissue avascularity on late gadolinium enhancement CMR affects cardiac mass identification by\n FDG<\/jats:styled-content>\n \u2010\n PET<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.011709","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T09:00:19Z","timestamp":1557478819000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Late Gadolinium Enhancement Cardiac Magnetic Resonance Tissue Characterization for Cancer\u2010Associated Cardiac Masses: Metabolic and Prognostic Manifestations in Relation to Whole\u2010Body Positron Emission Tomography"],"prefix":"10.1161","volume":"8","author":[{"given":"Angel T.","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center New York NY"},{"name":"Department of Radiology Memorial Sloan Kettering Cancer Center New York NY"},{"name":"Department of Medicine Icahn School of Medicine at Mt. Sinai New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Radiology Memorial Sloan Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Perez Johnston","sequence":"additional","affiliation":[{"name":"Department of Radiology Memorial Sloan Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Radiology Weill Cornell Medical College New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian R.","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Radiology Weill Cornell Medical College New York 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Epidemiology\/Biostatistics Memorial Sloan Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Steingart","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Weinsaft","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center New York NY"},{"name":"Department of Radiology Memorial Sloan Kettering Cancer Center New York NY"},{"name":"Departments of Medicine and Radiology Weill Cornell Medical College New York 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