{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:09:56Z","timestamp":1793333396208,"version":"4.5.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,5,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Left atrial (\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              ) function predicts clinical outcome in a variety of cardiovascular diseases. However, limited data are available in the setting of mitral regurgitation. The aim of the present study was to assess potential changes in\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              ejection fraction (LAEF) and its prognostic value in patients following transcatheter mitral valve repair using the MitraClip.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 88 consecutive patients undergoing MitraClip implantation with complete echocardiography at baseline and follow\u2010up between 3 and 6\u00a0months postprocedure were enrolled.\n              <jats:styled-content style=\"fixed-case\">LAEF<\/jats:styled-content>\n              improved in 58% of the population. Change in\n              <jats:styled-content style=\"fixed-case\">LAEF<\/jats:styled-content>\n              was associated with residual mitral regurgitation, residual transmitral gradient and left ventricular ejection fraction changes. Compared with their counterparts, patients with residual mitral regurgitation \u2265grade 2 (change in LAEF, \u22126% [Interquartile [IQR], \u22129\u20131%] versus 4% [IQR, \u22125\u201315%];\n              <jats:italic>P<\/jats:italic>\n              =0.05) and with residual transmitral gradient \u22655\u00a0mm\u00a0Hg (change in LAEF, \u22122% [IQR, \u22129\u20139%] versus 5% [IQR, \u22124\u201316%];\n              <jats:italic>P<\/jats:italic>\n              =0.03) showed a decline in\n              <jats:styled-content style=\"fixed-case\">LAEF<\/jats:styled-content>\n              , respectively. Furthermore,\n              <jats:styled-content style=\"fixed-case\">LAEF<\/jats:styled-content>\n              significantly correlated with changes in left ventricular ejection fraction (\n              <jats:italic>r<\/jats:italic>\n              =0.40;\n              <jats:italic>P<\/jats:italic>\n              =0.001). With regards to clinical outcome, heart failure symptoms as assessed by New York Heart Association class were more severe in patients with worsened\n              <jats:styled-content style=\"fixed-case\">LAEF<\/jats:styled-content>\n              at follow\u2010up. Finally,\n              <jats:styled-content style=\"fixed-case\">LAEF<\/jats:styled-content>\n              change was identified as an independent predictor of all\u2010cause mortality (hazard ratio, 0.94; 95% CI, 0.90\u20130.98 [\n              <jats:italic>P<\/jats:italic>\n              =0.008]).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The present analysis showed that changes in\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              function in patients undergoing MitraClip implantation are associated with important measures including residual mitral regurgitation, elevated transmitral gradient, and left ventricular function. Importantly,\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              function alterations represent a strong predictor for all\u2010cause mortality.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.011727","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T09:01:41Z","timestamp":1556874101000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Prognostic Impact of Left Atrial Function Following Transcatheter Mitral Valve Repair"],"prefix":"10.1161","volume":"8","author":[{"given":"Jakob","family":"Ledwoch","sequence":"first","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Innere Medizin I Klinikum rechts der Isar Technical University of Munich Germany"},{"name":"DZHK (German Center for Cardiovascular Research) Partner Site Munich Heart Alliance Munich 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