{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:01Z","timestamp":1787018101119,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,6,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The purpose of this study was to compare the incidence of pregnancy\u2010related adverse outcomes (\n                      <jats:styled-content style=\"fixed-case\">PRAO<\/jats:styled-content>\n                      ) between patients with versus without hemodynamically significant right ventricle outflow tract (\n                      <jats:styled-content style=\"fixed-case\">RVOT)<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      This was a retrospective cohort study of all pregnant patients with isolated\n                      <jats:styled-content style=\"fixed-case\">RVOT<\/jats:styled-content>\n                      lesions undergoing evaluation at the Mayo Clinic, 1990 to 2017. Hemodynamic significance was defined as \u2265moderate pulmonary\/conduit stenosis (\u22653\u00a0m\/s) and\/or \u2265moderate regurgitation. Patients with concomitant significant left heart disease were excluded.\n                      <jats:styled-content style=\"fixed-case\">PRAO<\/jats:styled-content>\n                      was defined as cardiovascular, obstetric, and\/or neonatal complications occurring during the pregnancy through 6\u00a0weeks postpartum. A total of 224 pregnancies in 114 patients with\n                      <jats:styled-content style=\"fixed-case\">RVOT<\/jats:styled-content>\n                      lesions were identified; 38 pregnancies occurred in 24 patients with hemodynamically significant\n                      <jats:styled-content style=\"fixed-case\">RVOT<\/jats:styled-content>\n                      . Forty\u2010eight (21%) pregnancies ended in spontaneous abortion. Of the 173 completed pregnancies, median gestational age at delivery was 38 (35\u201340) weeks and median birth weight 2965 (2065\u20134122) g. Seven pregnancies (4%) were complicated by cardiovascular events, 14 (8%) by obstetric complications, with adverse neonatal outcomes occurring in 38 (22%). There were no maternal deaths. The incidence of spontaneous abortion and\n                      <jats:styled-content style=\"fixed-case\">PRAO<\/jats:styled-content>\n                      were similar in both the\n                      <jats:styled-content style=\"fixed-case\">RVOT<\/jats:styled-content>\n                      and hemodynamically significant\n                      <jats:styled-content style=\"fixed-case\">RVOT<\/jats:styled-content>\n                      groups. As an isolated condition, Tetralogy of Fallot\u2013pulmonary atresia was associated with spontaneous abortion and neonatal complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The risk of cardiovascular complications was low in patients with isolated\n                      <jats:styled-content style=\"fixed-case\">RVOT<\/jats:styled-content>\n                      lesions, and hemodynamically significant\n                      <jats:styled-content style=\"fixed-case\">RVOT<\/jats:styled-content>\n                      lesions were not associated with either cardiovascular complications or\n                      <jats:styled-content style=\"fixed-case\">PRAO<\/jats:styled-content>\n                      . Further studies are required to explore the factors responsible for\n                      <jats:styled-content style=\"fixed-case\">PRAO<\/jats:styled-content>\n                      in patients with Tetralogy of Fallot\u2013pulmonary atresia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.118.011730","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T05:00:19Z","timestamp":1560488419000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Outcomes of Pregnancy in Patients With Prior Right Ventricular Outflow Interventions"],"prefix":"10.1161","volume":"8","author":[{"given":"Alexander C.","family":"Egbe","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester 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