{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:28:37Z","timestamp":1761215317785,"version":"3.41.2"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,8,20]]},"abstract":"\n Background<\/jats:title>\n \n Smoking is a significant risk factor for aortic stenosis but its impact on clinical and health status outcomes after transcatheter aortic valve replacement (\n TAVR<\/jats:styled-content>\n ) has not been described.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Patients (n=72\u00a0165) undergoing\n TAVR<\/jats:styled-content>\n at 457\n US<\/jats:styled-content>\n sites in the STS\/\n ACC TVT<\/jats:styled-content>\n (Society of Thoracic Surgeons\/American College of Cardiology Transcatheter Valve Therapy) Registry between November 2011 and June 2016 were categorized at the time of\n TAVR<\/jats:styled-content>\n as current\/recent smokers versus prior\/nonsmokers. A series of multivariable models examined the association between smoking status and outcomes, including 1\u2010year mortality, rehospitalization, mean gradient, and health status (measured by the 12\u2010item Kansas City Cardiomyopathy Questionnaire\u2013Overall Summary Score [\n KCCQ<\/jats:styled-content>\n \u2010\n OS<\/jats:styled-content>\n ]) and in\u2010hospital outcomes. A total of 4063 patients (5.6%) were smokers. Smokers presented for\n TAVR<\/jats:styled-content>\n at a younger age (75 [68\u201381] years versus 83 [77\u201388] years) but with a greater burden of cardiovascular and lung disease. In adjusted models, smoking was associated with lower in\u2010hospital mortality (relative risk, 0.74; 95%\n CI<\/jats:styled-content>\n , 0.62\u20130.89 [\n P<\/jats:italic>\n =0.001]) but not with in\u2010hospital stroke\/transient ischemic attack or myocardial infarction. Smoking status had no association with postdischarge mortality, stroke, myocardial infarction, or heart failure (HF) but was associated with slightly lower 1\u2010year\n KCCQ<\/jats:styled-content>\n \u2010\n OS<\/jats:styled-content>\n scores (2.4\u2010point lower\n KCCQ<\/jats:styled-content>\n \u2010\n OS<\/jats:styled-content>\n ; 95%\n CI<\/jats:styled-content>\n , \u22124.6 to \u22120.2 [\n P<\/jats:italic>\n =0.031]) and higher mean aortic valve gradients (11.1 versus 10.2\u00a0mm\u00a0Hg,\n P<\/jats:italic>\n <0.001) in adjusted models.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The current\/recent smoking rate in\n US<\/jats:styled-content>\n patients with TAVR is 5.6% and smokers present at a younger age for\n TAVR<\/jats:styled-content>\n . Smoking was associated with lower in\u2010hospital but similar long\u2010term survival after\n TAVR<\/jats:styled-content>\n , slightly worse long\u2010term health status, and marginally higher mean aortic valve gradients. Further research is needed to understand the effect of smoking cessation on outcomes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.011766","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T09:08:10Z","timestamp":1566205690000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Association of Smoking Status With Long\u2010Term Mortality and Health Status After Transcatheter Aortic Valve Replacement: Insights From the Society of Thoracic Surgeons\/American College of Cardiology Transcatheter Valve Therapy Registry"],"prefix":"10.1161","volume":"8","author":[{"given":"Mohammed","family":"Qintar","sequence":"first","affiliation":[{"name":"Saint Luke's Mid America Heart Institute and University of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuokai","family":"Li","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute and Division of Cardiology Duke University Medical Center Durham NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sreekanth","family":"Vemulapalli","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute and Division of Cardiology Duke University Medical Center Durham NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan K.","family":"Chhatriwalla","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute and University of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne J.","family":"Baron","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute and University of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej S.","family":"Kosinski","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute and Division of Cardiology Duke University Medical Center Durham NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Saxon","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute and University of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Spertus","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute and University of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute and University of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne V.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute and University of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.047"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.521708"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.7.733"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960141210"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.21.2497"},{"key":"e_1_3_1_7_2","first-page":"52","article-title":"Impact of smoking status on outcomes after concomitant aortic valve replacement and coronary artery bypass graft surgery","author":"Saxena A","year":"2014","unstructured":"Saxena A, Shan L, Dinh DT, Reid CM, Smith JA, Shardey GC, Newcomb AE. 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