{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:40:05Z","timestamp":1792194005180,"version":"4.4.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,5,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Secondary prevention after acute myocardial infarction (\n              <jats:styled-content style=\"fixed-case\">AMI<\/jats:styled-content>\n              ) requires long\u2010term guideline\u2010directed medical therapy. However, the level of medication adherence, factors associated with poor adherence, and extent to which good adherence can reduce adverse events after\n              <jats:styled-content style=\"fixed-case\">AMI<\/jats:styled-content>\n              in China remain uncertain.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In 2013 to 2014, 4001\n              <jats:styled-content style=\"fixed-case\">AMI<\/jats:styled-content>\n              patients aged \u226518\u00a0years were discharged alive from 53 hospitals across China (mean age 60.5\u00b111.7\u00a0years; 22.7% female). Good adherence was defined as taking medications (aspirin, \u03b2\u2010blockers, statins, clopidogrel, or angiotensin\u2010converting enzyme inhibitors\/angiotensin\u2010receptor blockers) \u226590% of the time as prescribed. Cox models assessed the association between good adherence (a time\u2010varying covariate) and 1\u2010year cardiovascular events after\n              <jats:styled-content style=\"fixed-case\">AMI<\/jats:styled-content>\n              . The most common medications were aspirin (82.2%) and statins (80.5%). There were 243 patients who were not prescribed any medications during follow\u2010up; 1\u2010year event rates were higher for these patients (25.1%, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              19.7\u201330.6%) versus those taking \u22651 medications (6.6%, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              5.76\u20137.34%). The overall rate of good adherence was 52.9%. Good adherence was associated with lower risk of 1\u2010year events (adjusted hazard ratio 0.61, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.49\u20130.77). The most common reason for poor adherence was belief that one's condition had improved\/no longer required medication. More comorbidities and lower education level were associated with poor adherence.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Good adherence reduced 1\u2010year cardiovascular event risk after\n              <jats:styled-content style=\"fixed-case\">AMI<\/jats:styled-content>\n              . About half of our cohort did not have good adherence. National efforts to improve\n              <jats:styled-content style=\"fixed-case\">AMI<\/jats:styled-content>\n              outcomes in China should focus on medication adherence and educating patients on the importance of cardiovascular medications for reducing risk of recurrent events.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              01624909.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.011793","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T14:56:20Z","timestamp":1557154580000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["Association Between Medication Adherence and 1\u2010Year Major Cardiovascular Adverse Events After Acute Myocardial Infarction in China"],"prefix":"10.1161","volume":"8","author":[{"given":"Pu","family":"Shang","sequence":"first","affiliation":[{"name":"School of International Pharmaceutical Business China Pharmaceutical University Nanjing China"},{"name":"NHC Key Laboratory of Clinical Research for Cardiovascular Medications National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Center for Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon G.","family":"Liu","sequence":"additional","affiliation":[{"name":"School of International Pharmaceutical Business China Pharmaceutical University Nanjing China"},{"name":"National School of Development Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Clinical Research for Cardiovascular Medications National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Center for Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Michael","family":"Ho","sequence":"additional","affiliation":[{"name":"Cardiology Section Rocky Mountain Regional VA Medical Center Aurora CO"},{"name":"Division of Cardiology University of Colorado School of Medicine Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Hu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Clinical Research for Cardiovascular Medications National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Center for Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Clinical Research for Cardiovascular Medications National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Center for Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Health Care and International Medical Services Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Li","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Clinical Research for Cardiovascular Medications National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Center for Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueke","family":"Bai","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Clinical Research for Cardiovascular Medications National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Center for Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Clinical Research for Cardiovascular Medications National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Center for Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xing","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Clinical Research for Cardiovascular Medications National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Center for Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Harvard T.H. 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