{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:42:39Z","timestamp":1789951359827,"version":"4.0.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,4,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Hyperkalemia has been associated with increased mortality in patients with myocardial infarction, but few data exist regarding hyperkalemia in cardiac intensive care unit (\n              <jats:styled-content style=\"fixed-case\">CICU<\/jats:styled-content>\n              ) patients. We hypothesize that hyperkalemia is associated with increased mortality in unselected\n              <jats:styled-content style=\"fixed-case\">CICU<\/jats:styled-content>\n              patients.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We retrospectively reviewed a historical cohort of 9681\n              <jats:styled-content style=\"fixed-case\">CICU<\/jats:styled-content>\n              patients admitted from January 2007 to December 2015. Hyperkalemia was defined as admission potassium \u22655.0\u00a0mEq\/L and hypokalemia as admission potassium &lt;3.5\u00a0mEq\/L. Multivariate logistic regression was used to determine predictors of in\u2010hospital mortality. Postdischarge survival was assessed using Kaplan\u2013Meier analysis and Cox proportional hazards models. The mean age of included patients was 67\u00b115\u00a0years, with 36% females, and in\u2010hospital mortality was 9%. Hyperkalemia occurred in 1187 (12.3%) and hypokalemia occurred in 719 (7.4%) patients. Both patients with hyperkalemia (unadjusted odds ratio, 2.85; 95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              2.40\u20133.39;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and patients with hypokalemia (unadjusted odds ratio, 2.31; 95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              1.85\u20132.88;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) were at increased risk of unadjusted in\u2010hospital mortality. After adjustment for illness severity and renal function, only patients with hyperkalemia demonstrated increased risk of in\u2010hospital death (adjusted odds ratio, 1.44; 95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              1.11\u20131.87;\n              <jats:italic>P<\/jats:italic>\n              =0.006). Among hospital survivors, only patients with hyperkalemia had lower postdischarge survival by Kaplan\u2013Meier analysis (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). After adjustment for illness severity and renal function, hospital survivors with admission hyperkalemia remained at increased risk for postdischarge mortality (adjusted hazard ratio, 1.20; 95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              1.08\u20131.34;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Hyperkalemia on\n              <jats:styled-content style=\"fixed-case\">CICU<\/jats:styled-content>\n              admission is associated with higher in\u2010hospital and postdischarge mortality, independent of renal function and illness severity. These findings emphasize the importance of potassium abnormalities as a risk predictor in patients admitted to the\n              <jats:styled-content style=\"fixed-case\">CICU<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.011814","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T09:00:47Z","timestamp":1553850047000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Hyperkalemia Is Associated With Increased Mortality Among Unselected Cardiac Intensive Care Unit Patients"],"prefix":"10.1161","volume":"8","author":[{"given":"Benjamin","family":"Brueske","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine Albany Medical Center Albany NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep S.","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Albany Medical Center Albany NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Schulman\u2010Marcus","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Albany Medical Center Albany NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kianoush B.","family":"Kashani","sequence":"additional","affiliation":[{"name":"Division of Nephrology &amp; Hypertension Department of Internal Medicine Mayo Clinic Rochester MN"},{"name":"Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Barsness","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob C.","family":"Jentzer","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Mayo Clinic Rochester MN"},{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2017.07.006"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487318759694"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0720-9"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198510000-00009"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008169"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885066617741873"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0479"},{"key":"e_1_3_1_9_2","volume-title":"Common Terminology Criteria for Adverse Events (CTCAE)","author":"National Cancer Institute (US)","year":"2009","unstructured":"National Cancer Institute (US) . 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Kidney Int Suppl. 2012;2:1\u2013138.","journal-title":"Kidney Int Suppl"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2017.04.001"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000216"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2164"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.04.015"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.08.012"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2016.03.008"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx460"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000479802"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2636-7"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00002.2005"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.06.060"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.166563"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000509"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182742c84"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.000792"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181cb0a63"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.118.011814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:44:05Z","timestamp":1715600645000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.118.011814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,2]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,4,2]]}},"alternative-id":["10.1161\/JAHA.118.011814"],"URL":"https:\/\/doi.org\/10.1161\/jaha.118.011814","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,2]]},"assertion":[{"value":"2018-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e011814"}}