{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:23:16Z","timestamp":1780701796004,"version":"3.54.1"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,3,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Although studies have shown that statin therapy in patients with non\u2013dialysis\u2010dependent chronic kidney disease was associated with a lower risk of death, this was not observed in dialysis patients newly initiated on statins. It is unclear if statin therapy benefits administered during the predialysis period persist after transitioning to end\u2010stage renal disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In 47\u00a0720 veterans who transitioned to end\u2010stage renal disease during 2007 to 2014, we examined the association of statin therapy use 1\u00a0year before transition with posttransition all\u2010cause and cardiovascular mortality and hospitalization incidence rates over the first 12 months of follow\u2010up. Associations were examined using multivariable adjusted Cox proportional hazard models and negative binomial regressions. Sensitivity analyses included propensity score and subgroup analyses. The cohort's mean\u00b1\n              <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n              age was 71\u00b111\u00a0years, and the cohort included 4% women, 23% blacks, and 66% diabetics. Over 12\u00a0months of follow\u2010up, there were 13\u00a0411 deaths, with an incidence rate of 35.3 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 34.7\u201335.8) deaths per 100 person\u2010years. In adjusted models, statin therapy compared with no statin therapy was associated with lower risks of 12\u2010month all\u2010cause (hazard ratio [95% CI], 0.79 [0.76\u20130.82]) and cardiovascular (hazard ratio [95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              ], 0.83 [0.78\u20130.88]) mortality, as well as with a lower rate of hospitalizations (incidence rate ratio [95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              ], 0.89 [0.87\u20130.92]) after initiating dialysis. These lower outcome risks persisted across strata of clinical characteristics, and in propensity score analyses.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among veterans with non\u2013dialysis\u2010dependent chronic kidney disease, treatment with statin therapy within the 1\u00a0year before transitioning to end\u2010stage renal disease is associated with favorable early end\u2010stage renal disease outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.011869","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T09:00:57Z","timestamp":1552986057000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Statin Therapy Before Transition to End\u2010Stage Renal Disease With Posttransition Outcomes"],"prefix":"10.1161","volume":"8","author":[{"given":"Melissa","family":"Soohoo","sequence":"first","affiliation":[{"name":"Harold Simmons Center for Kidney Disease Research and Epidemiology Division of Nephrology and Hypertension University of California Irvine Medical Center Orange CA"},{"name":"Nephrology Section Tibor Rubin Veterans Affairs Medical Center Long Beach CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Moradi","sequence":"additional","affiliation":[{"name":"Harold Simmons Center for Kidney Disease Research and Epidemiology Division of Nephrology and Hypertension University of California Irvine Medical Center Orange CA"},{"name":"Nephrology Section Tibor Rubin Veterans Affairs Medical Center Long Beach CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitsugu","family":"Obi","sequence":"additional","affiliation":[{"name":"Harold Simmons Center for Kidney Disease Research and Epidemiology Division of 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