{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:22:48Z","timestamp":1787502168596,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,4,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      To define benign intracerebral hemorrhage (\n                      <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>\n                      ) and to investigate the association between benign\n                      <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>\n                      , hematoma expansion, and functional outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We analyzed a prospectively collected cohort of patients with ICH, who presented within 6\u00a0hours of symptom onset between July 2011 and February 2017 to a tertiary teaching hospital. Follow\u2010up computed tomographic scanning was performed within 36\u00a0hours after initial computed tomographic scanning. Benign\n                      <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>\n                      was operationally defined as homogeneous and regularly shaped small\n                      <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>\n                      . The presence of benign\n                      <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>\n                      was judged by 2 independent reviewers (Q.L., W.Y.) on the basis of the admission computed tomographic scan. Functional independence was defined as a modified Rankin Scale score of 0 to 2 at 3\u00a0months. The associations between benign\n                      <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>\n                      , hematoma expansion, and functional outcome were assessed by using multivariable logistic regression analyses. A total of 288 patients with\n                      <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>\n                      were included. Benign\n                      <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>\n                      was found in 48 patients (16.7%). None of the patients with benign\n                      <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>\n                      had early hematoma expansion. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of benign\n                      <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>\n                      for predicting functional independence at 3\u00a0months were 30.7%, 96.6%, 90.0%, 60.0%, and 0.637, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Patients with benign\n                      <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>\n                      are at low risk of hematoma expansion and poor outcome. These patients may be safe for less intensive monitoring and are unlikely to benefit from therapies aimed at preventing\n                      <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>\n                      expansion.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.118.011892","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T05:47:36Z","timestamp":1554961656000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Benign Intracerebral Hemorrhage: A Population at Low Risk for Hematoma Growth and Poor Outcome"],"prefix":"10.1161","volume":"8","author":[{"given":"Qi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Song","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Qing","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong\u2010Fei","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Ting","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa\u2010Jin","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Rong","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Feng","family":"Wu","sequence":"additional","affiliation":[{"name":"Emergency Department The Affiliated Hospital of Guizhou Medical University Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou\u2010Ping","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua N.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Division of Neurocritical Care and Emergency Neurology Massachusetts General Hospital Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60371-8"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70340-0"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.556324"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000258078.35316.30"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000346599"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000208408.98482.99"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318260cbba"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5433"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.4.891"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002897"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001076"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182343387"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.1218"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009185"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013186"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017985"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.014425"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183082"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000477179"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70069-3"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214609"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.8.1304"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182143317"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.7.1500"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493015616635"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-018-0507-y"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603460"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.015060"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.1014"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004210"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b8b332"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000078657.22835.B9"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.118.011892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:07:57Z","timestamp":1715584077000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.118.011892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,16]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,4,16]]}},"alternative-id":["10.1161\/JAHA.118.011892"],"URL":"https:\/\/doi.org\/10.1161\/jaha.118.011892","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,16]]},"assertion":[{"value":"2019-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e011892"}}