{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:00Z","timestamp":1787018100938,"version":"build-2736575974"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,8,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Lean body mass has been identified as a key determinant of left ventricular mass and wall thickness. However, the importance of lean body mass or other body\u2010size measures as normative determinants of carotid intima\u2010media thickness (\n                      <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n                      ), a widely used early indicator of atherosclerosis, has not been well established.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Carotid artery ultrasound measurements of\n                      <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n                      and carotid artery plaque burden (derived from plaque number and maximum size) and measurements of body size, including height, body mass index, weight, body fat proportion, and lean body mass ([1\u2212body fat proportion]\u00d7weight), were recorded in 25\u00a0020 participants from 10 regions of China. Analyses were restricted to a healthy younger subset (n=6617) defined as never or long\u2010term ex\u2010regular smokers aged &lt;60\u00a0years (mean age, 50) without previous ischemic heart disease, stroke, diabetes mellitus, or hypertension and with plasma non\u2010high\u2010density lipoprotein cholesterol &lt;4\u00a0mmol\/L. Among these 6617 participants, 86% were women (because most men smoked) and 9% had carotid artery plaque. In both women and men separately, lean body mass was strongly positively associated with\n                      <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n                      , but was not associated with plaque burden: overall, each 10 kg higher lean body mass was associated with a 0.03 (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 0.03\u20130.04) mm higher\n                      <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      =5\u00d710\n                      <jats:sup>\u221233<\/jats:sup>\n                      ). Fat mass, height, and other body\u2010size measures were more weakly associated with\n                      <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The strong association of lean body mass with\n                      <jats:styled-content style=\"fixed-case\">cIMT,<\/jats:styled-content>\n                      but not with plaque burden, in healthy adults suggests a normative relationship rather than reflecting atherosclerotic pathology. Common mechanisms may underlie the associations of lean body mass with\n                      <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n                      and with nonatherosclerotic vascular traits.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.118.011919","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T05:20:38Z","timestamp":1564550438000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Carotid Intima\u2010Media Thickness but Not Carotid Artery Plaque in Healthy Individuals Is Linked to Lean Body Mass"],"prefix":"10.1161","volume":"8","author":[{"given":"Matthew","family":"Arnold","sequence":"first","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit Nuffield Department of Population Health University of Oxford Oxford United 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