{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:55:26Z","timestamp":1789397726714,"version":"build-2803163510"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,3,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Thoracic aortic aneurysm is common in patients with tetralogy of Fallot (\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              ); the incidence of thoracic aortic dissection (\n              <jats:styled-content style=\"fixed-case\">TAD<\/jats:styled-content>\n              ) is unknown, but generally considered to be uncommon. The purpose of this study was to determine incidence and risk factors for\n              <jats:styled-content style=\"fixed-case\">TAD<\/jats:styled-content>\n              in\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              patients.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This work is a retrospective review of the National Inpatient Sample (\n              <jats:styled-content style=\"fixed-case\">NIS<\/jats:styled-content>\n              ) database for cases of ascending\n              <jats:styled-content style=\"fixed-case\">TAD<\/jats:styled-content>\n              among all hospital admissions in adults with\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              , 2000\u20132014. Of 18\u00a0353 admissions in\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              patients, 11 (0.06%; 6 per 10\u00a0000 admissions) of these were\n              <jats:styled-content style=\"fixed-case\">TAD<\/jats:styled-content>\n              \u2010related admissions. For the\n              <jats:styled-content style=\"fixed-case\">TAD<\/jats:styled-content>\n              \u2010related admissions, mean age was 49.8\u00b17.2\u00a0years; aortic surgical interventions were performed during 8 of the admissions, and overall in\u2010hospital mortality was 45% (5 of 11). Risk factors associated with\n              <jats:styled-content style=\"fixed-case\">TAD<\/jats:styled-content>\n              \u2010related admission were age &gt;60\u00a0years (odds ratio, 2.41; 95% CI, 1.23\u20133.25;\n              <jats:italic>P<\/jats:italic>\n              =0.013), male sex (\n              <jats:styled-content style=\"fixed-case\">odds ratio,<\/jats:styled-content>\n              6.91; 95% CI, 4.85\u20138.54;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and hypertension (odds ratio, 1.74; 95% CI, 1.06\u20133.19;\n              <jats:italic>P<\/jats:italic>\n              =0.037).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This is the first population\u2010based study of\n              <jats:styled-content style=\"fixed-case\">TAD<\/jats:styled-content>\n              outcomes in patients with\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              , and it showed a low risk of\n              <jats:styled-content style=\"fixed-case\">TAD<\/jats:styled-content>\n              in this population. This has important clinical implication with regard to surveillance and surgical intervention. Given that prevalence of thoracic aortic aneurysm is higher in\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              patients compared with the general population; therefore, making clinical decisions based on outcomes data and practice guidelines derived from patients with degenerative and bicuspid aortic valve\u2013related aortopathies may lead to\n              <jats:italic>overtreatment<\/jats:italic>\n              . Further studies are required to better understand the pathobiology of this disease in order to make evidence\u2010based recommendations for surveillance and treatment.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.011943","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T09:01:57Z","timestamp":1552640517000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Thoracic Aortic Dissection in Tetralogy of Fallot: A Review of the National Inpatient Sample Database"],"prefix":"10.1161","volume":"8","author":[{"given":"Alexander C.","family":"Egbe","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Crestanello","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi M.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-016-0902-4"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.09.113"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.129585"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.01.021"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.015"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu281"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.02.115"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.07.002"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezr032"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14046"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.05.037"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.04.167"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.03.026"},{"key":"e_1_3_1_15_2","unstructured":"Introduction to the HCUP Nationwide Inpatient Sample 2009. 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