{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T03:04:59Z","timestamp":1776740699069,"version":"3.51.2"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,5,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We evaluated the importance of high\u2010density lipoprotein (HDL) functionality for target\u2010lesion revascularization in patients treated with coronary stents using a rapid cell\u2010free assay system to evaluate the functional capacity of HDL to accept additional cholesterol (cholesterol\u2010uptake capacity; CUC).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              From an optical coherence tomography (OCT) registry of patients treated with coronary stents, 207 patients were enrolled and their HDL was functionally evaluated by measuring the CUC. Follow\u2010up OCT was performed (median duration, 24.5\u00a0months after stenting) to evaluate the presence of neoatherosclerosis. Clinical follow\u2010up was performed to assess target\u2010lesion revascularization for a median duration of 42.3\u00a0months after stent implantation. Neoatherosclerosis was identified in 37 patients (17.9%). Multivariate logistic regression analysis revealed that a decreased CUC was independently associated with neoatherosclerosis (odds ratio, 0.799;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The CUC showed a significant inverse correlation with incidence of target\u2010lesion revascularization (odds ratio, 0.887;\n              <jats:italic>P<\/jats:italic>\n              =0.003) and with lipid accumulation inside stents, suggesting that neoatherosclerosis contributes to the association between CUC and target\u2010lesion revascularization.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Impaired HDL functionality, detected as decreased CUC, might lead to future stent failure by provoking atherogenic changes of the neointima within stents. Both quantitative and qualitative assessments of HDL might enable the improved prediction of clinical outcomes after stent implantation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.011975","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T09:06:58Z","timestamp":1555578418000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Impaired Cholesterol\u2010Uptake Capacity of HDL Might Promote Target\u2010Lesion Revascularization by Inducing Neoatherosclerosis After Stent Implantation"],"prefix":"10.1161","volume":"8","author":[{"given":"Yuichiro","family":"Nagano","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Internal Medicine Kobe University Graduate School of Medicine Kobe 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