{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:28:20Z","timestamp":1792290500679,"version":"4.4.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,7,16]]},"abstract":"\n Background<\/jats:title>\n \n Myocardial infarction with nonobstructive coronary arteries (\n MINOCA<\/jats:styled-content>\n ) is a heterogeneous disease entity. Its prognosis and predictor of mortality remain unclear. This study aimed to compare the prognosis between\n MINOCA<\/jats:styled-content>\n and myocardial infarction with obstructive coronary artery disease and identify factors related to all\u2010cause death in\n MINOCA<\/jats:styled-content>\n using a nation\u2010wide, multicenter, and prospective registry.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Among 13\u00a0104 consecutive patients enrolled, patients without previous history of significant coronary artery disease who underwent coronary angiography were selected. The primary outcome was 2\u2010year all\u2010cause death. Secondary outcomes were cardiac death, noncardiac death, reinfarction, and repeat revascularization. Patients with\n MINOCA<\/jats:styled-content>\n (n=396) and myocardial infarction with obstructive coronary artery disease (n=10\u00a0871) showed similar incidence of all\u2010cause death (9.1% versus 8.8%; hazard ratio [\n HR<\/jats:styled-content>\n ], 1.04; 95% CI, 0.74\u20131.45;\n P<\/jats:italic>\n =0.83). Risks of cardiac death, noncardiac death, and reinfarction were not significantly different between the 2 groups (\n HR<\/jats:styled-content>\n , 0.82; 95%\n CI<\/jats:styled-content>\n , 0.53\u20131.28;\n P<\/jats:italic>\n =0.38;\n HR<\/jats:styled-content>\n , 1.55; 95%\n CI<\/jats:styled-content>\n , 0.93\u20132.56;\n P<\/jats:italic>\n =0.09;\n HR<\/jats:styled-content>\n , 1.23; 95%\n CI<\/jats:styled-content>\n , 0.65\u20132.31;\n P<\/jats:italic>\n =0.38, respectively).\n MINOCA<\/jats:styled-content>\n patients had lower incidence of repeat revascularization (1.3% versus 7.2%;\n HR<\/jats:styled-content>\n , 0.17; 95%\n CI<\/jats:styled-content>\n , 0.07\u20130.41;\n P<\/jats:italic>\n <0.001). Results were consistent after multivariable regression and propensity\u2010score matching. In a multivariate model, several significant predictors of all\u2010cause death of\n MINOCA<\/jats:styled-content>\n were found, including the nonuse of renin\u2010angiotensin system blockers (\n HR<\/jats:styled-content>\n , 2.63; 95%\n CI<\/jats:styled-content>\n , 1.08\u20136.25;\n P<\/jats:italic>\n =0.033) and statins (\n HR<\/jats:styled-content>\n , 2.17; 95%\n CI<\/jats:styled-content>\n , 1.04\u20134.54;\n P<\/jats:italic>\n =0.039).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Patients with\n MINOCA<\/jats:styled-content>\n and those with myocardial infarction with obstructive coronary artery disease had comparable clinical outcomes. Use of renin\u2010angiotensin system blockers and statins was associated with lower mortality in patients with\n MINOCA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.011990","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T09:00:19Z","timestamp":1562662819000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":132,"title":["Prognosis and Predictors of Mortality in Patients Suffering Myocardial Infarction With Non\u2010Obstructive Coronary Arteries"],"prefix":"10.1161","volume":"8","author":[{"given":"Eun Ho","family":"Choo","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Cardiology The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyuk","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Cardiology The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Cardiology The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjae","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Cardiology The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Gyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Cardiology The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngkeun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Heart Center Chonnam National University Hospital Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Yeungnam University Medical Center Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shung Chull","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyungpook National University Hospital Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong Chan","family":"Cho","sequence":"additional","affiliation":[{"name":"Cardiology Division Department of Internal Medicine Chungbuk National University Hospital Cheongju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyunghee University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiovascular Center Seoul National University Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Ho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Heart Center Chonnam National University Hospital Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"KAMIR\u2010NIH Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","first-page":"143","article-title":"ESC working group position paper on myocardial infarction with non\u2010obstructive coronary arteries","volume":"38","author":"Agewall S","year":"2017","unstructured":"Agewall S, Beltrame JF, Reynolds HR, Niessner A, Rosano G, Caforio AL, De Caterina R, Zimarino M, Roffi M, Kjeldsen K, Atar D, Kaski JC, Sechtem U, Tornvall P. 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