{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:55:20Z","timestamp":1787774120457,"version":"build-2784847793"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Intracranial atherosclerotic stroke is prevalent in Asians. We hypothesized that patients with the ring finger protein 213 (\n              <jats:italic>RNF213<\/jats:italic>\n              ) variant, a susceptibility locus for moyamoya disease in Asians, have different neuroimaging characteristics in terms of the vessel wall and hemodynamics.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We analyzed consecutive patients with ischemic events in middle cerebral artery distribution and relevant plaques of the distal internal carotid artery or proximal middle cerebral artery on high\u2010resolution magnetic resonance imaging. Patients with carotid\/cardiac sources of embolism or moyamoya disease were excluded. High\u2010resolution magnetic resonance imaging features (eg, outer vessel diameters and plaque characteristics) and fractional flow (as measured by adjusted signal intensity ratio on time\u2010of\u2010flight magnetic resonance angiography) were compared between\n              <jats:italic>RNF213<\/jats:italic>\n              p.Arg4810Lys variant carriers and noncarriers. Among 144 patients included, 44 (29.9%) had the\n              <jats:italic>RNF213<\/jats:italic>\n              variant. Clinical characteristics, including age, sex, body mass index, and vascular risk factors, were not significantly different between\n              <jats:italic>RNF213<\/jats:italic>\n              variant carriers and noncarriers. However, the outer vessel diameter was smaller in\n              <jats:italic>RNF213<\/jats:italic>\n              variant carriers than in noncarriers (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001 for middle cerebral artery of relevant stenosis [2.05\u2010mm analysis of RNF213 gene for moyamoya disease in the Chinese HAN population 2.75\u00a0mm];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001 for contralateral side [2.42\u00a0 versus 3.00\u00a0mm] and\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for basilar artery [3.19\u00a0versus 3.53\u00a0mm]). Other high\u2010resolution magnetic resonance imaging features, including plaque morphology and eccentricity, were not significantly different. Fractional flow was diminished in patients with smaller\u2010diameter intracranial arteries with a similar degree of stenosis.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The\n              <jats:italic>RNF213<\/jats:italic>\n              variant may be associated with vasculogenesis, but not with atherogenesis. Patients with this variant had small intracranial arteries predisposing hemodynamic compromise in the presence of intracranial atherosclerosis. In addition to antiatherosclerotic strategies, further studies are warranted to develop novel therapeutic strategies against\n              <jats:italic>RNF213<\/jats:italic>\n              vasculopathy in Asians.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.011996","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T09:00:18Z","timestamp":1570525218000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":36,"title":["Ring Finger Protein 213 Variant and Plaque Characteristics, Vascular Remodeling, and Hemodynamics in Patients With Intracranial Atherosclerotic Stroke: A High\u2010Resolution Magnetic Resonance Imaging and Hemodynamic Study"],"prefix":"10.1161","volume":"8","author":[{"given":"Eun\u2010Hyeok","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Won","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"},{"name":"Translational and Stem Cell Research Laboratory on Stroke Samsung Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo\u2010Keun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeong\u2010Moon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Seok","family":"Ki","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Genetics Green Cross Genome Youngin Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon\u2010Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Samsung Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh Young","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"},{"name":"Translational and Stem Cell Research Laboratory on Stroke Samsung Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.05.017"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.1.14"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2006.01.003"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.496588"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.03.033"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2014.16.1.27"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70234-X"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12199-015-0498-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.107927"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2010.132"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022542"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.663864"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002477"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130663"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006459"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.08.048"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(97)00082-6"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.004761"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010894"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013495"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12101"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12080"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156607"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179689"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.4103\/sni.sni_59_17"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37829"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.09.023"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.67"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3171\/2013.9.JNS131000"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.07.004"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000070546.16946.3A"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016662039"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110354200"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090171"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.021888"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.578229"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.641563"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00413-4"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2014.16.2.65"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.01760"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12199-012-0299-1"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048179"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006244"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0058-3"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.52.299"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.011996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:31:12Z","timestamp":1715599872000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.011996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,15]]},"references-count":45,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2019,10,15]]}},"alternative-id":["10.1161\/JAHA.119.011996"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.011996","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,15]]},"assertion":[{"value":"2019-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e011996"}}