{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:10:34Z","timestamp":1790737834068,"version":"4.1.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,7,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">In contrast to the general population, outcome\u2010derived thresholds for diagnosing ambulatory hypertension in pregnancy are not yet available. We aimed to identify and compare outcome\u2010derived ambulatory blood pressure (BP) monitoring thresholds for adverse perinatal outcomes by using approaches related and not related to clinic BP in a southern Chinese population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Ambulatory BP monitoring was performed in a cohort of 1768 high\u2010risk participants in late pregnancy who were not taking antihypertensive medications. Participants were followed for composite maternal (severe complications) and neonatal (pregnancy loss, advanced neonatal care, and small for gestational age) outcomes. Modeling of clinic BP\u2013unrelated approaches revealed a nonlinear threshold effect of ambulatory diastolic BP on the composite outcome, with increased risk for daytime \u226579\u00a0mm\u00a0Hg and 24\u2010hour measurement \u226576\u00a0mm\u00a0Hg. For other ambulatory BP components showing linear associations with outcome, the following thresholds were identified: 131\u00a0mm\u00a0Hg for daytime systolic, 121\u00a0mm\u00a0Hg for nighttime systolic, 130\u00a0mm\u00a0Hg for 24\u2010hour systolic, and 73\u00a0mm\u00a0Hg for night\u2010time diastolic BP. These thresholds unrelated to clinic BP were lower than the equivalents yielding a similar probability of outcome to clinic BP of 140\/90\u00a0mm\u00a0Hg and were comparable with equivalents to clinic BP of 130\/80\u00a0mm\u00a0Hg.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Using an outcome\u2010derived approach unrelated to clinic BP, we identified rounded thresholds to define ambulatory hypertension in at\u2010risk women in late pregnancy in a southern Chinese population as follows: 130\/80\u00a0mm\u00a0Hg for daytime, 120\/75\u00a0mm\u00a0Hg for nighttime, and 130\/75\u00a0mm\u00a0Hg for 24\u2010hour measurement. For wider clinical applicability and to align both nonpregnancy and pregnancy ambulatory BP monitoring with an outcomes\u2010based approach, prospective, multiethnic, international studies from early pregnancy onward will be required.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.012027","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T09:08:09Z","timestamp":1562144889000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Thresholds for Ambulatory Blood Pressure Monitoring Based on Maternal and Neonatal Outcomes in Late Pregnancy in a Southern Chinese Population"],"prefix":"10.1161","volume":"8","author":[{"given":"Li\u2010Juan","family":"Lv","sequence":"first","affiliation":[{"name":"Medical Genetics Centre Guangdong Women and Children Hospital Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Jie","family":"Ji","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury Pingjin Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2010Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Shenzhen Maternity and Child Healthcare Hospital Southern Medical University Shenzhen Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Miao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury Pingjin Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Ying","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Guangdong Women and Children Hospital Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Guangdong Women and Children Hospital Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Mei","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Guangdong Women and Children Hospital Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health at Peking University Health Science Center (PUHSC) Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Hirst","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health Nuffield Department of Women's &amp; 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