{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:54:12Z","timestamp":1768704852639,"version":"3.49.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The impact of estimated glomerular filtration rate (\n              <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n              ) on clinical short\u2010term outcomes after stroke thrombolysis with tissue plasminogen activator remains controversial.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We analyzed 18\u00a0320 ischemic stroke patients who received intravenous tissue plasminogen activator at participating hospitals in the Chinese Stroke Center Alliance between June 2015 and November 2017. Multivariate logistic regression models were used to evaluate associations between\n              <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n              (&lt;45, 45\u201359, 60\u201389, and \u226590\u00a0mL\/min per 1.73\u00a0m\n              <jats:sup>2<\/jats:sup>\n              ) and in\u2010hospital mortality and symptomatic intracerebral hemorrhage, adjusting for patient and hospital characteristics and the hospital clustering effect. Of the 18\u00a0320 patients receiving tissue plasminogen activator, 601 (3.3%) had an\n              <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n              &lt;45, 625 (3.4%) had an\n              <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n              45 to 59, 3679 (20.1%) had an\n              <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n              60 to 89, and 13\u00a0415 (73.2%) had an\n              <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n              \u226590. As compared with\n              <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n              \u226590,\n              <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n              values &lt;45 (6.7% versus 0.9%, adjusted odds ratio, 3.59; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 2.18\u20135.91), 45 to 59 (4.0% versus 0.9%, adjusted odds ratio, 2.00; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.18\u20133.38), and 60 to 89 (2.5% versus 0.9%, adjusted odds ratio, 1.67; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.20\u20132.34) were independently associated with increased odds of in\u2010hospital mortality. However, there was no statistically significant association between\n              <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n              and symptomatic intracerebral hemorrhage.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n              was associated with an increased risk of in\u2010hospital mortality in acute ischemic stroke patients after treatment with tissue plasminogen activator.\n              <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n              is an important predictor of poststroke short\u2010term death but not of symptomatic intracerebral hemorrhage.\n            <\/jats:p>\n          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