{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:50:35Z","timestamp":1791377435218,"version":"4.3.2"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,6,18]]},"abstract":"\n Background<\/jats:title>\n \n Premature coronary artery disease (\n CAD<\/jats:styled-content>\n ) is common in patients with coarctation of aorta (\n COA<\/jats:styled-content>\n ), but there are limited data about any direct relationship (or lack thereof) between\n COA<\/jats:styled-content>\n and\n CAD<\/jats:styled-content>\n . We hypothesized that atherosclerotic cardiovascular disease risk factors, rather than\n COA<\/jats:styled-content>\n diagnosis, was the primary determinant of\n CAD<\/jats:styled-content>\n occurrence in patients with\n COA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n This is a retrospective study of 654\n COA<\/jats:styled-content>\n patients and a control group of 876 patients with valvular pulmonic stenosis and tetralogy of Fallot to determine prevalence and independent risk factors for\n CAD<\/jats:styled-content>\n . There was no evidence of a difference in the unadjusted\n CAD<\/jats:styled-content>\n prevalence between the\n COA<\/jats:styled-content>\n and control groups (7.8% versus 6.3%,\n P<\/jats:italic>\n =0.247), but premature\n CAD<\/jats:styled-content>\n was more common in\n COA<\/jats:styled-content>\n patients (4.4% versus 1.8%,\n P<\/jats:italic>\n =0.002). In the analysis of a propensity\u2010matched cohort of 126\n COA<\/jats:styled-content>\n and 126 control patients, there was no evidence of a difference in overall\n CAD<\/jats:styled-content>\n prevalence (6.3% versus 5.6% versus\n P<\/jats:italic>\n =0.742) and premature\n CAD<\/jats:styled-content>\n prevalence (4.8% versus 3.2%,\n P<\/jats:italic>\n =0.518). The multivariable risk factors for\n CAD<\/jats:styled-content>\n were hypertension (odds ratio [\n OR<\/jats:styled-content>\n ] 2.14; 95%\n CI<\/jats:styled-content>\n 1.36\u20133.38), hyperlipidemia (\n OR<\/jats:styled-content>\n 3.33; 95%\n CI<\/jats:styled-content>\n 2.02\u20135.47), diabetes mellitus (\n OR<\/jats:styled-content>\n 1.98; 95%\n CI<\/jats:styled-content>\n 1.31\u20133.61), male sex (\n OR<\/jats:styled-content>\n 2.05; 95%\n CI<\/jats:styled-content>\n 1.33\u20133.17), and older age per year (\n OR<\/jats:styled-content>\n 1.06; 95%\n CI<\/jats:styled-content>\n 1.04\u20131.07).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n After adjusting for atherosclerotic cardiovascular disease risk factors, we did not find evidence of a difference in\n CAD<\/jats:styled-content>\n risk between the patients with\n COA<\/jats:styled-content>\n and other patients with congenital heart disease.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.012056","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T05:02:13Z","timestamp":1560488533000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Coronary Artery Disease in Adults With Coarctation of Aorta: Incidence, Risk Factors, and Outcomes"],"prefix":"10.1161","volume":"8","author":[{"given":"Alexander C.","family":"Egbe","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charanjit S.","family":"Rihal","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Thomas","sequence":"additional","affiliation":[{"name":"Mayo Medical School Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Boler","sequence":"additional","affiliation":[{"name":"Mayo Medical School Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandini","family":"Mehra","sequence":"additional","affiliation":[{"name":"Mayo Medical School Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Andersen","sequence":"additional","affiliation":[{"name":"Mayo Medical School Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanth","family":"Kothapalli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel W.","family":"Taggart","sequence":"additional","affiliation":[{"name":"Divsion of Pediatric Cardiology Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi M.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.057182"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.195065"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-014-0884-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.925172"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.06.016"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.57.5.462"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.4.840"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02293-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.088294"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.03.529"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.013"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2018.02.004"},{"key":"e_1_3_2_14_2","unstructured":"ACC\/AHA . ASCVD Risk Estimator. Available at: http:\/\/tools.acc.org\/ASCVD-Risk-Estimator-Plus\/#!\/calculate\/estimate\/. Accessed November 11 2018."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.005"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)40976-8"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.08.051"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.006"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.1029"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.012056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:50:40Z","timestamp":1715586640000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.012056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,18]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,6,18]]}},"alternative-id":["10.1161\/JAHA.119.012056"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.012056","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,18]]},"assertion":[{"value":"2019-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e012056"}}