{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:33:14Z","timestamp":1791487994415,"version":"4.3.4"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,8,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Amlodipine is used for the treatment of hypertension, but reports on its use in early pregnancy are limited.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In the present study, we recruited 231 women with chronic hypertension, including those who received amlodipine or other antihypertensives during early pregnancy, and investigated frequencies of morphologic abnormalities in their 231 offspring. Specifically, we evaluated 48 neonates exposed to amlodipine in the first trimester (amlodipine group, Group A), 54 neonates exposed to antihypertensives other than amlodipine (other antihypertensive group, Group O), and 129 neonates not exposed to antihypertensives (no\u2010antihypertensive group, Group N). The number of morphologic abnormalities of offspring in each group were 2 in Group A (4.2%; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 0.51\u201314.25); 3 in Group O (5.6%; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.16\u201315.39) and 6 in Group N (4.7%; 95% CI, 1.73\u20139.85). The odds ratio of the primary outcome comparing Group A and Group O was 0.74 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              : 0.118\u20134.621) and Group A and Group N was 0.89 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              : 0.174\u20134.575).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The odds of birth defects in Group A in the first trimester were not significantly different from those with or without other antihypertensives.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.012093","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T09:00:16Z","timestamp":1564131616000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Safety of Amlodipine in Early Pregnancy"],"prefix":"10.1161","volume":"8","author":[{"given":"Asako","family":"Mito","sequence":"first","affiliation":[{"name":"Drug Information Institute in Pregnancy Tokyo Japan"},{"name":"Division of Maternal Medicine Center for Maternal\u2010Fetal\u2010Neonatal and Reproductive Medicine National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Murashima","sequence":"additional","affiliation":[{"name":"Drug Information Institute in Pregnancy Tokyo Japan"},{"name":"Division of Maternal Medicine Center for Maternal\u2010Fetal\u2010Neonatal and Reproductive Medicine National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Obstetric Medicine Osaka Women's and Children's Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Miyasato\u2010Isoda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (I) Osaka Medical College Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizuko A.","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Perinatology and Gynecology National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Waguri","sequence":"additional","affiliation":[{"name":"Department of Obstetric Medicine Osaka Women's and Children's Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yoshimatsu","sequence":"additional","affiliation":[{"name":"Department of Perinatology and Gynecology National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naho","family":"Yakuwa","sequence":"additional","affiliation":[{"name":"Drug Information Institute in Pregnancy Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Drug Information Institute in Pregnancy Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Drug Information Institute in Pregnancy Tokyo Japan"},{"name":"Division of Obstetrics Center for Maternal\u2010Fetal\u2010Neonatal and Reproductive Medicine National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Arata","sequence":"additional","affiliation":[{"name":"Drug Information Institute in Pregnancy Tokyo Japan"},{"name":"Division of Maternal Medicine Center for Maternal\u2010Fetal\u2010Neonatal and Reproductive Medicine National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Mikami","sequence":"additional","affiliation":[{"name":"Division of Biostatistics Clinical Research Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Ito","sequence":"additional","affiliation":[{"name":"Motherisk Program Division of Clinical Pharmacology and Toxicology Department of Paediatrics The Hospital for Sick Children University of Toronto Toronto 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