{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:24:26Z","timestamp":1781594666851,"version":"3.54.5"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,7,16]]},"abstract":"\n Background<\/jats:title>\n \n Excess transmission of pressure pulsatility caused by increased arterial stiffness may incur microcirculatory damage in end organs (target organ damage\n [TOD]<\/jats:styled-content>\n ) and, in turn, elevate risk for cardiovascular disease (\n CVD<\/jats:styled-content>\n ) events.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We related arterial stiffness measures (carotid\u2010femoral pulse wave velocity, mean arterial pressure, central pulse pressure) to the prevalence and incidence of\n TOD<\/jats:styled-content>\n (defined as albuminuria and\/or echocardiographic left ventricular hypertrophy) in up to 6203 Framingham Study participants (mean age 50\u00b115\u00a0years, 54% women). We then related presence of\n TOD<\/jats:styled-content>\n to incident\n CVD<\/jats:styled-content>\n in multivariable Cox regression models without and with adjustment for arterial stiffness measures. Cross\u2010sectionally, greater arterial stiffness was associated with a higher prevalence of\n TOD<\/jats:styled-content>\n (adjusted odds ratios ranging from 1.23 to 1.54 per\n SD<\/jats:styled-content>\n increment in arterial stiffness measure,\n P<\/jats:italic>\n <0.01). Prospectively, increased carotid\u2010femoral pulse wave velocity was associated with incident albuminuria (odds ratio per\n SD<\/jats:styled-content>\n 1.28, 95%\n CI,<\/jats:styled-content>\n 1.02\u20131.61;\n P<\/jats:italic>\n <0.05), whereas higher mean arterial pressure and central pulse pressure were associated with incident left ventricular hypertrophy (odds ratio per\n SD<\/jats:styled-content>\n 1.37 and 1.45, respectively;\n P<\/jats:italic>\n <0.01). On follow\u2010up, 297 of 5803 participants experienced a first\n CVD<\/jats:styled-content>\n event. Presence of\n TOD<\/jats:styled-content>\n was associated with a 33% greater hazard of incident\n CVD<\/jats:styled-content>\n (95%\n CI<\/jats:styled-content>\n , 0\u201377%;\n P<\/jats:italic>\n <0.05), which was attenuated upon adjustment for baseline arterial stiffness measures by 5\u201321%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Elevated arterial stiffness is associated with presence of\n TOD<\/jats:styled-content>\n and may partially mediate the relations of\n TOD<\/jats:styled-content>\n with incident\n CVD<\/jats:styled-content>\n . Our observations in a large community\u2010based sample suggest that mitigating arterial stiffness may lower the burden of\n TOD<\/jats:styled-content>\n and, in turn, clinical\n CVD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.012141","type":"journal-article","created":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T09:00:16Z","timestamp":1563008416000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":111,"title":["Interrelations Between Arterial Stiffness, Target Organ Damage, and Cardiovascular Disease Outcomes"],"prefix":"10.1161","volume":"8","author":[{"given":"Ramachandran S.","family":"Vasan","sequence":"first","affiliation":[{"name":"National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA"},{"name":"Section\u00a0of Preventive Medicine Department of Medicine Boston University School of Medicine Boston MA"},{"name":"Section\u00a0of Cardiology Department of Medicine Boston University School of Medicine Boston MA"},{"name":"Department of Epidemiology Boston University School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan I.","family":"Short","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Boston University School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teemu J.","family":"Niiranen","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA"},{"name":"Department of Medicine Turku University Hospital and University of Turku Finland"},{"name":"Department of Public Health Solutions National Institute for Health and Welfare Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Xanthakis","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA"},{"name":"Section\u00a0of Preventive Medicine Department of Medicine Boston University School of Medicine Boston MA"},{"name":"Department of Biostatistics Boston University School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"University of California Davis CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Cheng","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA"},{"name":"Smidt Heart Institute Cedars\u2010Sinai Medical Center Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA"},{"name":"Biggs Institute for Alzheimer's Disease University of Texas Health Sciences Center at San Antonio TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary F.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Cardiovascular Engineering, Inc. 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