{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:55:07Z","timestamp":1770281707258,"version":"3.49.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,7,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Evidence accumulated that some glucose\u2010lowering medications protect against cardiovascular events (\n              <jats:styled-content style=\"fixed-case\">CVEs<\/jats:styled-content>\n              ) in patients with type 2 diabetes mellitus (T2DM) and established cardiovascular disease. The present study evaluated if and how glucose\u2010lowering medication prescription pattern changes in T2DM after a CVE.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              DATAFILE (Diabetes Therapy After a Cardiovascular Event) was a retrospective multicenter study conducted at 12 diabetes mellitus specialist outpatient clinics in Italy. We identified T2DM patients with an incident\n              <jats:styled-content style=\"fixed-case\">CVE<\/jats:styled-content>\n              for whom a follow\u2010up visit was available after the event. We selected control T2DM patients without an incident\n              <jats:styled-content style=\"fixed-case\">CVE<\/jats:styled-content>\n              , who were matched with cases for age, sex, known diabetes mellitus duration, baseline hemoglobin A\n              <jats:sub>1c<\/jats:sub>\n              , kidney function, and follow\u2010up time. We extracted clinical variables and compared prescribed therapies at baseline and follow\u2010up. We included 563 patients with and 497 matched patients without an incident\n              <jats:styled-content style=\"fixed-case\">CVE<\/jats:styled-content>\n              . As expected, patients with a subsequent\n              <jats:styled-content style=\"fixed-case\">CVE<\/jats:styled-content>\n              had a higher baseline prevalence of ischemic heart disease. After a median of 9.5\u00a0months, in patients with versus those without a\n              <jats:styled-content style=\"fixed-case\">CVE<\/jats:styled-content>\n              , there was a significant increase in the prescription of beta\u2010blockers, loop diuretics, dual antiplatelet therapy, and, among glucose\u2010lowering medications, a significant decrease in metformin. Hemoglobin A\n              <jats:sub>1c<\/jats:sub>\n              marginally declined only in the control group, whereas low\u2010density lipoprotein cholesterol decreased only in patients with\n              <jats:styled-content style=\"fixed-case\">CVE<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This study highlights that occurrence of a\n              <jats:styled-content style=\"fixed-case\">CVE<\/jats:styled-content>\n              in T2DM patients did not prime the prescription of glucose\u2010lowering medications provided with cardiovascular protective effects, even though glucose control remained poor. These data emphasize the need to optimize the therapeutic regimen of T2DM patients with established cardiovascular disease, according to updated guidelines.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.012244","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T14:07:37Z","timestamp":1562249257000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Changes in the Prescription of Glucose\u2010Lowering Medications in Patients With Type 2 Diabetes Mellitus After a Cardiovascular Event: A Call to Action From the DATAFILE Study"],"prefix":"10.1161","volume":"8","author":[{"given":"Gian Paolo","family":"Fadini","sequence":"first","affiliation":[{"name":"Department of Medicine University of Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Frison","sequence":"additional","affiliation":[{"name":"Diabetology Service ULSS6 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