{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:28:39Z","timestamp":1788222519928,"version":"build-2803163510"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,9,3]]},"abstract":"\n Background<\/jats:title>\n \n Autonomic dysregulation represents a hallmark of coronary artery disease (\n CAD<\/jats:styled-content>\n ). Therefore, we investigated the effects of exercise\u2010based cardiac rehabilitation (\n CR<\/jats:styled-content>\n ) on autonomic function and neuro\u2010cardiovascular stress reactivity in\n CAD<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Twenty\u2010two\n CAD<\/jats:styled-content>\n patients (4 women; 62\u00b18\u00a0years) were studied before and following 6 months of aerobic\u2010 and resistance\u2010training\u2013based\n CR<\/jats:styled-content>\n . Twenty\u2010two similarly aged, healthy individuals (\n CTRL<\/jats:styled-content>\n ; 7 women; 62\u00b111\u00a0years) served as controls. We measured blood pressure, muscle sympathetic nerve activity, heart rate, heart rate variability (linear and nonlinear), and cardiovagal (sequence method) and sympathetic (linear relationship between burst incidence and diastolic blood pressure) baroreflex sensitivity during supine rest. Furthermore, neuro\u2010cardiovascular reactivity during short\u2010duration static handgrip (20s) at 40% maximal effort was evaluated. Six months of\n CR<\/jats:styled-content>\n lowered resting blood pressure (\n P<\/jats:italic>\n <0.05), as well as muscle sympathetic nerve activity burst frequency (48\u00b18 to 39\u00b111\u00a0bursts\/min;\n P<\/jats:italic>\n <0.001) and burst incidence (81\u00b17 to 66\u00b117 bursts\/100 heartbeats;\n P<\/jats:italic>\n <0.001), to levels that matched\n CTRL<\/jats:styled-content>\n and improved sympathetic baroreflex sensitivity in\n CAD<\/jats:styled-content>\n patients (\n P<\/jats:italic>\n <0.01). Heart rate variability (all\n P<\/jats:italic>\n >0.05) and cardiovagal baroreflex sensitivity (\n P<\/jats:italic>\n =0.11) were unchanged following\n CR<\/jats:styled-content>\n , yet values were not different pre\u2010\n CR<\/jats:styled-content>\n from\n CTRL<\/jats:styled-content>\n (all\n P<\/jats:italic>\n >0.05). Furthermore, before\n CR<\/jats:styled-content>\n ,\n CAD<\/jats:styled-content>\n patients displayed greater blood pressure and muscle sympathetic nerve activity reactivity to static handgrip versus\n CTRL<\/jats:styled-content>\n (all\n P<\/jats:italic>\n <0.05); yet, responses were reduced following\n CR<\/jats:styled-content>\n (all\n P<\/jats:italic>\n <0.05) to levels observed in\n CTRL<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Six months of exercise\u2010based\n CR<\/jats:styled-content>\n was associated with marked improvement in baseline autonomic function and neuro\u2010cardiovascular stress reactivity in\n CAD<\/jats:styled-content>\n patients, which may play a role in the reduced cardiac risk and improved survival observed in patients following exercise training.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.012257","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T09:04:09Z","timestamp":1566551049000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Effects of 6 Months of Exercise\u2010Based Cardiac Rehabilitation on Autonomic Function and Neuro\u2010Cardiovascular Stress Reactivity in Coronary Artery Disease Patients"],"prefix":"10.1161","volume":"8","author":[{"given":"Mark B.","family":"Badrov","sequence":"first","affiliation":[{"name":"School of Kinesiology Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn N.","family":"Wood","sequence":"additional","affiliation":[{"name":"School of Kinesiology Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lalande","sequence":"additional","affiliation":[{"name":"School of Kinesiology Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn P.","family":"Sawicki","sequence":"additional","affiliation":[{"name":"School of Kinesiology Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay J.","family":"Borrell","sequence":"additional","affiliation":[{"name":"School of Kinesiology Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly C.","family":"Barron","sequence":"additional","affiliation":[{"name":"School of Kinesiology Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Vording","sequence":"additional","affiliation":[{"name":"School of Kinesiology Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene","family":"Fleischhauer","sequence":"additional","affiliation":[{"name":"School of Kinesiology Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neville","family":"Suskin","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation and Secondary Prevention Program of St. Joseph's Health Care London London Ontario Canada"},{"name":"Department of Medicine (Cardiology) and Program of Experimental Medicine Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheri L.","family":"McGowan","sequence":"additional","affiliation":[{"name":"School of Kinesiology Western University London Ontario Canada"},{"name":"Department of Kinesiology University of Windsor Windsor Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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